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    Kcnmb2 potassium large conductance calcium-activated channel, subfamily M, beta member 2 [ Mus musculus (house mouse) ]

    Gene ID: 72413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcnmb2provided by MGI
    Official Full Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 2provided by MGI
    Primary source
    MGI:MGI:1919663
    See related
    Ensembl:ENSMUSG00000037610 AllianceGenome:MGI:1919663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700049B16Rik; 3110031N04Rik
    Summary
    Predicted to enable calcium-activated potassium channel activity and potassium channel regulator activity. Predicted to be involved in detection of calcium ion; neuronal action potential; and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in ascending aorta and ductus arteriosus. Orthologous to human KCNMB2 (potassium calcium-activated channel subfamily M regulatory beta subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Kcnmb2 in Genome Data Viewer
    Location:
    3 A3; 3 15.48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (31956021..32254329)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (31901861..32200180)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07327 Neighboring gene predicted gene, 54171 Neighboring gene predicted gene 6558 Neighboring gene STARR-seq mESC enhancer starr_07328 Neighboring gene predicted gene, 33886 Neighboring gene predicted gene, 34031 Neighboring gene STARR-seq mESC enhancer starr_07329 Neighboring gene STARR-seq mESC enhancer starr_07330 Neighboring gene STARR-seq mESC enhancer starr_07331 Neighboring gene STARR-seq mESC enhancer starr_07332 Neighboring gene predicted gene, 42201 Neighboring gene predicted gene, 37770 Neighboring gene predicted gene, 57708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperaldosteronism after decreased renal K+ excretion in KCNMB2 knockout mice. Larsen CK, et al. Am J Physiol Renal Physiol, 2016 May 15. PMID 26962098
    2. Intact colonic K(C)(a)1.1 channel activity in KCNMB2 knockout mice. Larsen CK, et al. Physiol Rep, 2017 Mar. PMID 28292889, Free PMC Article
    3. BK channel inactivation gates daytime excitability in the circadian clock. Whitt JP, et al. Nat Commun, 2016 Mar 4. PMID 26940770, Free PMC Article
    4. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. Martinez-Espinosa PL, et al. J Gen Physiol, 2014 Oct. PMID 25267913, Free PMC Article
    5. Transcriptional profiling reveals ductus arteriosus-specific genes that regulate vascular tone. Shelton EL, et al. Physiol Genomics, 2014 Jul 1. PMID 24790087, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC57945

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of calcium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium-activated potassium channel subunit beta-2
    Names
    BK channel subunit beta-2
    BKbeta2
    calcium-activated potassium channel, subfamily M subunit beta-2
    charybdotoxin receptor subunit beta-2
    k(VCA)beta-2
    maxi K channel subunit beta-2
    slo-beta-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429175.1 → NP_001416104.1  calcium-activated potassium channel subunit beta-2

      Status: VALIDATED

      Source sequence(s)
      AC115930, AC156552, AC158571
      UniProtKB/Swiss-Prot
      Q9CZM9

    2. NM_028231.3 → NP_082507.1  calcium-activated potassium channel subunit beta-2

      See identical proteins and their annotated locations for NP_082507.1

      Status: VALIDATED

      Source sequence(s)
      AC115930, AC156552, AC158571
      Consensus CDS
      CCDS17292.1
      UniProtKB/Swiss-Prot
      Q9CZM9
      Related
      ENSMUSP00000113234.2, ENSMUST00000119970.8
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      31956021..32254329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535550.3 → XP_006535613.1  calcium-activated potassium channel subunit beta-2 isoform X2

      See identical proteins and their annotated locations for XP_006535613.1

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    2. XM_006535549.5 → XP_006535612.1  calcium-activated potassium channel subunit beta-2 isoform X2

      Related
      ENSMUSP00000112531.2, ENSMUST00000119310.8
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    3. XM_006535548.5 → XP_006535611.1  calcium-activated potassium channel subunit beta-2 isoform X1

      Conserved Domains (2) summary
      pfam09303
      Location:31 → 61
      KcnmB2_inactiv; KCNMB2, ball and chain domain
      pfam03185
      Location:67 → 258
      CaKB; Calcium-activated potassium channel, beta subunit

    4. XM_036163350.1 → XP_036019243.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    5. XM_006535551.4 → XP_006535614.1  calcium-activated potassium channel subunit beta-2 isoform X2

      See identical proteins and their annotated locations for XP_006535614.1

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain

    6. XM_017319742.3 → XP_017175231.1  calcium-activated potassium channel subunit beta-2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CZM9
      Conserved Domains (2) summary
      pfam03185
      Location:38 → 229
      CaKB; Calcium-activated potassium channel, beta subunit
      pfam09303
      Location:2 → 32
      KcnmB2_inactiv; KCNMB2, ball and chain domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZM9.1 GenPept UniProtKB/Swiss-Prot:Q9CZM9

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