foxa2.L forkhead box A2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: foxa2.L
Official Full Name: forkhead box A2 L homeolog
Primary source: Xenbase:XB-GENE-865381
Locus tag: XELAEV_18026543mg
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: foxa2; hnf3b; xFD-3; FoxA2a; HNF-3B; FoxA2-A; xbeta-1; hnf3beta; hnf3-beta
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Genomic context

Location:: chromosome: 5L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (34770683..34773186)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (34018741..34021244)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE).
Title: Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling.
HNF3beta target genes function to limit the extent of mesoderm formation in the Xenopus gastrula.
Title: Inhibition of mesodermal fate by Xenopus HNF3beta/FoxA2.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: forkhead box protein A2-A

Names: HNF-3-beta-A; HNF3-beta homolog A; HNF3-beta-A; Hepatocyte nuclear factor 3-beta homolog A; fork head domain-related protein 3; xHNF3-beta-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172158.1 → NP_001165629.1 forkhead box protein A2-A

See identical proteins and their annotated locations for NP_001165629.1

Status: PROVISIONAL

Source sequence(s)

L25637

UniProtKB/Swiss-Prot

Q91765

UniProtKB/TrEMBL

A0A974CTX3

Conserved Domains (3) summary

smart00339
Location:149 → 237

FH; FORKHEAD

pfam08430
Location:17 → 148

Forkhead_N; Forkhead N-terminal region

pfam09354
Location:349 → 423

HNF_C; HNF3 C-terminal domain