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    birc2.S baculoviral IAP repeat containing 2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 100036859, updated on 18-Sep-2024

    Summary

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    Official Symbol
    birc2.S
    Official Full Name
    baculoviral IAP repeat containing 2 S homeolog
    Primary source
    Xenbase:XB-GENE-17343783
    Locus tag
    XELAEV_18016254mg
    See related
    EnsemblRapid:ENSXLAG00005020813
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    api1; mihb; ciap1; hiap2; rnf48; c-iap1; hiap-2
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    Genomic context

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    See birc2.S in Genome Data Viewer
    Location:
    chromosome: 2S
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (150704278..150746287)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (141736207..141755533)

    Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene protein mono-ADP-ribosyltransferase PARP4 Neighboring gene centrosomal protein of 126 kDa-like Neighboring gene Yes associated protein 1 S homeolog Neighboring gene transmembrane protein 123 S homeolog Neighboring gene matrix metalloproteinase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of necroptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of programmed cell death IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100036859

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097144.1 → NP_001090613.1  uncharacterized protein LOC100036859

      See identical proteins and their annotated locations for NP_001090613.1

      Status: PREDICTED

      Source sequence(s)
      BC129545
      UniProtKB/TrEMBL
      A1L2I6
      Conserved Domains (5) summary
      smart00238
      Location:31 → 101
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:252 → 319
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:371 → 420
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      pfam13920
      Location:548 → 593
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl14633
      Location:431 → 525
      DD; Death Domain Superfamily of protein-protein interaction domains

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      150704278..150746287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041582906.1 → XP_041438840.1  uncharacterized protein LOC100036859 isoform X1

      UniProtKB/TrEMBL
      A0A1L8HAT1, A0A974DJP2
      Related
      ENSXLAP00005061100.1, ENSXLAT00005062553.1
      Conserved Domains (6) summary
      smart00238
      Location:41 → 111
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:262 → 329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:381 → 430
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:556 → 609
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:178 → 242
      BIR; Inhibitor of Apoptosis domain
      cl14633
      Location:441 → 535
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_041582905.1 → XP_041438839.1  uncharacterized protein LOC100036859 isoform X1

      UniProtKB/TrEMBL
      A0A1L8HAT1, A0A974DJP2
      Conserved Domains (6) summary
      smart00238
      Location:41 → 111
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:262 → 329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:381 → 430
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:556 → 609
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:178 → 242
      BIR; Inhibitor of Apoptosis domain
      cl14633
      Location:441 → 535
      DD; Death Domain Superfamily of protein-protein interaction domains

    3. XM_041582907.1 → XP_041438841.1  uncharacterized protein LOC100036859 isoform X2

      UniProtKB/TrEMBL
      A0A8J1MBV8
      Related
      ENSXLAP00005061118.1, ENSXLAT00005062570.1
      Conserved Domains (6) summary
      smart00238
      Location:41 → 111
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:262 → 329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:381 → 430
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:542 → 595
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:178 → 242
      BIR; Inhibitor of Apoptosis domain
      cl14633
      Location:441 → 531
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_041582904.1 → XP_041438838.1  uncharacterized protein LOC100036859 isoform X1

      UniProtKB/TrEMBL
      A0A1L8HAT1, A0A974DJP2
      Related
      ENSXLAP00005061112.1, ENSXLAT00005062564.1
      Conserved Domains (6) summary
      smart00238
      Location:41 → 111
      BIR; Baculoviral inhibition of apoptosis protein repeat
      cd00022
      Location:262 → 329
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd14394
      Location:381 → 430
      UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
      cd16713
      Location:556 → 609
      RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
      pfam00653
      Location:178 → 242
      BIR; Inhibitor of Apoptosis domain
      cl14633
      Location:441 → 535
      DD; Death Domain Superfamily of protein-protein interaction domains
    Nucleotide Protein Strain
    Heading Accession and Version

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