Sar1a secretion associated Ras related GTPase 1A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sar1aprovided by MGI
Official Full Name: secretion associated Ras related GTPase 1Aprovided by MGI
Primary source: MGI:MGI:98230
See related: Ensembl:ENSMUSG00000020088 AllianceGenome:MGI:98230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sara; Sara1; 1600019H17Rik
Summary: Predicted to enable G protein activity and amino acid sensor activity. Acts upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Located in Golgi apparatus and sarcoplasmic reticulum. Is expressed in several structures, including genitourinary system; liver; nervous system; retina nuclear layer; and skeletal musculature. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 41.8), bladder adult (RPKM 39.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B4; 10 32.26 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (61516096..61529076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (61680285..61693297)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Title: Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.
Title: Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH135930 (e-PCR)
- UniSTS:209927

AW538165 (e-PCR)
- UniSTS:208539

SAR1A (e-PCR)
- UniSTS:503011

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables G protein activity	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amino acid sensor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	ISO Inferred from Sequence Orthology more info
involved_in COPII vesicle coating	ISS Inferred from Sequence or Structural Similarity more info
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in COPII-coated vesicle cargo loading	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cargo loading into COPII-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of COPII vesicle coating	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
part_of COPII vesicle coat	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small COPII coat GTPase SAR1A; GTP-binding protein SAR1a

Names: SAR1 gene homolog A; SAR1a gene homolog 1

NP_001345416.1

EC 3.6.5.2

NP_001345417.1

EC 3.6.5.2

NP_001393258.1

EC 3.6.5.2

NP_001393259.1

EC 3.6.5.2

NP_001393260.1

EC 3.6.5.2

NP_001393261.1

EC 3.6.5.2

NP_001393262.1

EC 3.6.5.2

NP_001393263.1

EC 3.6.5.2

NP_001393264.1

EC 3.6.5.2

NP_001393265.1

EC 3.6.5.2

NP_001393266.1

EC 3.6.5.2

NP_001393267.1

EC 3.6.5.2

NP_001393268.1

EC 3.6.5.2

NP_001393269.1

EC 3.6.5.2

NP_033146.1

EC 3.6.5.2

XP_006513464.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358487.2 → NP_001345416.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

Consensus CDS

CCDS23883.1

UniProtKB/TrEMBL

Q3TXJ4, Q99JZ4

Conserved Domains (1) summary

cd00879
Location:3 → 197

Sar1; Sar1 is an essential component of COPII vesicle coats
NM_001358488.2 → NP_001345417.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

Consensus CDS

CCDS23883.1

UniProtKB/TrEMBL

Q3TXJ4, Q99JZ4

Conserved Domains (1) summary

cd00879
Location:3 → 197

Sar1; Sar1 is an essential component of COPII vesicle coats
NM_001406329.1 → NP_001393258.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406330.1 → NP_001393259.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406331.1 → NP_001393260.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4

Related

ENSMUSP00000151383.2, ENSMUST00000219506.2
NM_001406332.1 → NP_001393261.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406333.1 → NP_001393262.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406334.1 → NP_001393263.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406335.1 → NP_001393264.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406336.1 → NP_001393265.1 small COPII coat GTPase SAR1A isoform 1

Status: VALIDATED

Source sequence(s)

AC124421

UniProtKB/TrEMBL

Q99JZ4
NM_001406337.1 → NP_001393266.1 small COPII coat GTPase SAR1A isoform 2

Status: VALIDATED

Source sequence(s)

AC124421
NM_001406338.1 → NP_001393267.1 small COPII coat GTPase SAR1A isoform 3

Status: VALIDATED

Source sequence(s)

AC124421
NM_001406339.1 → NP_001393268.1 small COPII coat GTPase SAR1A isoform 3

Status: VALIDATED

Source sequence(s)

AC124421
NM_001406340.1 → NP_001393269.1 small COPII coat GTPase SAR1A isoform 4

Status: VALIDATED

Source sequence(s)

AC124421
NM_009120.4 → NP_033146.1 small COPII coat GTPase SAR1A isoform 1

See identical proteins and their annotated locations for NP_033146.1

Status: VALIDATED

Source sequence(s)

AC124421

Consensus CDS

CCDS23883.1

UniProtKB/TrEMBL

Q3TXJ4, Q99JZ4

Related

ENSMUSP00000020285.9, ENSMUST00000020285.10

Conserved Domains (1) summary

cd00879
Location:3 → 197

Sar1; Sar1 is an essential component of COPII vesicle coats