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    Eloc elongin C [ Mus musculus (house mouse) ]

    Gene ID: 67923, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Elocprovided by MGI
    Official Full Name
    elongin Cprovided by MGI
    Primary source
    MGI:MGI:1915173
    See related
    Ensembl:ENSMUSG00000079658 AllianceGenome:MGI:1915173
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tceb1; 2610043E24Rik; 2610301I15Rik
    Summary
    Predicted to enable protein-macromolecule adaptor activity and transcription corepressor binding activity. Predicted to be involved in RNA metabolic process; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Part of Cul5-RING ubiquitin ligase complex and elongin complex. Is expressed in several structures, including alimentary system; cerebral cortex; ganglia; musculature; and nose. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 25.1), frontal lobe adult (RPKM 20.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eloc in Genome Data Viewer
    Location:
    1 A3; 1 5.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (16711949..16727652, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (16641725..16657428, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene RIKEN cDNA C130013N14 gene Neighboring gene ubiquitin-conjugating enzyme E2W (putative) Neighboring gene STARR-positive B cell enhancer ABC_E4305 Neighboring gene RIKEN cDNA D030040B21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5743 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells. Limnander A, et al. Mol Cell, 2004 Aug 13. PMID 15304214
    2. TCEB1 promotes invasion of prostate cancer cells. Jalava SE, et al. Int J Cancer, 2009 Jan 1. PMID 18844214
    3. Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Kim YK, et al. Acta Crystallogr D Biol Crystallogr, 2013 Aug. PMID 23897481
    4. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. Desimone MC, et al. J Natl Cancer Inst, 2013 Sep 18. PMID 23990666, Free PMC Article
    5. The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. Babon JJ, et al. J Mol Biol, 2008 Sep 12. PMID 18590740, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape.
      Title: EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
    2. EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells.
      Title: EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.
    3. Crystal structure shows interaction between SOCS2-elongin BC and Cullin-5.
      Title: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
    4. PRAME expression in leukaemic cell lines is upregulated by IFN gamma and LPS, suggesting a possible role in immune responses. PRAME associates with Elongin BC complexes by binding Elongin C.
      Title: PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.
    5. TCEB1 promotes invasion of prostate cancer cells and is involved in development of hormone-refractory prostate cancer
      Title: TCEB1 promotes invasion of prostate cancer cells.
    6. Elongin B/C recruitment regulates substrate binding by CIS
      Title: Elongin B/C recruitment regulates substrate binding by CIS.
    7. SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation.
      Title: The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in target-directed miRNA degradation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul5-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of elongin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongin-C
    Names
    RNA polymerase II transcription factor SIII subunit C
    SIII p15
    elongin 15 kDa subunit
    stromal membrane-associated protein SMAP1B homolog
    transcription elongation factor B (SIII), polypeptide 1
    transcription elongation factor B polypeptide 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310470.2 → NP_001297399.1  elongin-C isoform 1

      See identical proteins and their annotated locations for NP_001297399.1

      Status: VALIDATED

      Source sequence(s)
      AC157362
      Consensus CDS
      CCDS78549.1
      UniProtKB/TrEMBL
      A0A087WNT1
      Related
      ENSMUSP00000139480.2, ENSMUST00000187910.7
      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    2. NM_001430012.1 → NP_001416941.1  elongin-C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/TrEMBL
      A0A087WNT1

    3. NM_001430013.1 → NP_001416942.1  elongin-C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/TrEMBL
      A0A087WNT1

    4. NM_001430014.1 → NP_001416943.1  elongin-C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/TrEMBL
      A0A087WNT1

    5. NM_001430015.1 → NP_001416944.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    6. NM_001430016.1 → NP_001416945.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    7. NM_001430017.1 → NP_001416946.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    8. NM_001430018.1 → NP_001416947.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    9. NM_001430019.1 → NP_001416948.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    10. NM_001430020.1 → NP_001416949.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    11. NM_001430021.1 → NP_001416950.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    12. NM_001430022.1 → NP_001416951.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    13. NM_001430023.1 → NP_001416952.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    14. NM_001430024.1 → NP_001416953.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    15. NM_001430025.1 → NP_001416954.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    16. NM_001430026.1 → NP_001416955.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    17. NM_001430028.1 → NP_001416957.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    18. NM_001430030.1 → NP_001416959.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    19. NM_001430032.1 → NP_001416961.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    20. NM_001430033.1 → NP_001416962.1  elongin-C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157362
      UniProtKB/Swiss-Prot
      P83940, Q63182

    21. NM_026456.5 → NP_080732.1  elongin-C isoform 2

      See identical proteins and their annotated locations for NP_080732.1

      Status: VALIDATED

      Source sequence(s)
      AC157362
      Consensus CDS
      CCDS35517.1
      UniProtKB/Swiss-Prot
      P83940, Q63182
      UniProtKB/TrEMBL
      A0A087WQE6
      Related
      ENSMUSP00000140422.2, ENSMUST00000188641.7
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      16711949..16727652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495561.3 → XP_006495624.1  elongin-C isoform X2

      Related
      ENSMUSP00000111009.4, ENSMUST00000115352.10
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    2. XM_006495564.3 → XP_006495627.1  elongin-C isoform X2

      Related
      ENSMUSP00000140962.2, ENSMUST00000186948.7
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    3. XM_011238403.3 → XP_011236705.1  elongin-C isoform X1

      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    4. XM_006495559.4 → XP_006495622.1  elongin-C isoform X1

      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    5. XM_006495562.3 → XP_006495625.1  elongin-C isoform X2

      Related
      ENSMUSP00000139675.2, ENSMUST00000185771.7
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    6. XM_006495558.4 → XP_006495621.1  elongin-C isoform X1

      See identical proteins and their annotated locations for XP_006495621.1

      UniProtKB/TrEMBL
      A0A087WNT1
      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    7. XM_006495563.4 → XP_006495626.1  elongin-C isoform X2

      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    8. XM_030242571.2 → XP_030098431.1  elongin-C isoform X1

      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    9. XM_036153232.1 → XP_036009125.1  elongin-C isoform X1

      UniProtKB/TrEMBL
      A0A087WNT1
      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    10. XM_030242577.2 → XP_030098437.1  elongin-C isoform X2

      UniProtKB/Swiss-Prot
      P83940, Q63182
      UniProtKB/TrEMBL
      A0A087WQE6
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    11. XM_036153239.1 → XP_036009132.1  elongin-C isoform X2

      UniProtKB/Swiss-Prot
      P83940, Q63182
      UniProtKB/TrEMBL
      A0A087WQE6
      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    12. XM_030242579.1 → XP_030098439.1  elongin-C isoform X2

      Conserved Domains (1) summary
      cd18321
      Location:18 → 112
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

    13. XM_017322272.2 → XP_017177761.1  elongin-C isoform X1

      UniProtKB/TrEMBL
      A0A087WNT1
      Conserved Domains (1) summary
      cd18321
      Location:40 → 134
      BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83940.1 GenPept UniProtKB/Swiss-Prot:P83940

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