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    Tm7sf3 transmembrane 7 superfamily member 3 [ Mus musculus (house mouse) ]

    Gene ID: 67623, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tm7sf3provided by MGI
    Official Full Name
    transmembrane 7 superfamily member 3provided by MGI
    Primary source
    MGI:MGI:1914873
    See related
    Ensembl:ENSMUSG00000040234 AllianceGenome:MGI:1914873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NARP1; 2010003B14Rik
    Summary
    Involved in cellular response to unfolded protein and negative regulation of programmed cell death. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human TM7SF3 (transmembrane 7 superfamily member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 11.6), limb E14.5 (RPKM 9.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm7sf3 in Genome Data Viewer
    Location:
    6 G3; 6 77.7 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (146503774..146536103, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (146602276..146634605, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 13 Neighboring gene FGFR1 oncogene partner 2 Neighboring gene STARR-positive B cell enhancer ABC_E1076 Neighboring gene mediator complex subunit 21 Neighboring gene RIKEN cDNA 4930479D17 gene Neighboring gene predicted pseudogene 6654

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis. Wu YJ, et al. Parasit Vectors, 2021 Mar 10. PMID 33691755, Free PMC Article
    2. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Isaac R, et al. Cell Death Differ, 2017 Jan. PMID 27740623, Free PMC Article
    3. An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells. Beck A, et al. Diabetologia, 2011 Nov. PMID 21853325
    4. TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Isaac R, et al. Cell Metab, 2024 May 7. PMID 38670107,
    5. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Nathan BM, et al. Endocrinology, 2006 Nov. PMID 16873534

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The NF-kappaB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
      Title: The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis.
    2. Data indicate that TM7SF3 plays a role in inhibition of cytokine-induced cell death/apoptosis in pancreatic beta cells and in inhibition of insulin secretion from pancreatic beta cells.
      Title: An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of programmed cell death IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane 7 superfamily member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026281.2 → NP_080557.2  transmembrane 7 superfamily member 3 precursor

      See identical proteins and their annotated locations for NP_080557.2

      Status: VALIDATED

      Source sequence(s)
      AC124128, AK010720
      Consensus CDS
      CCDS20699.1
      UniProtKB/Swiss-Prot
      Q3TBQ2, Q3U3Q6, Q4F873, Q6PES5, Q9CRG1
      UniProtKB/TrEMBL
      A0A0R4J0K4
      Related
      ENSMUSP00000045650.10, ENSMUST00000037709.16
      Conserved Domains (1) summary
      pfam13886
      Location:291 → 498
      DUF4203; Domain of unknown function (DUF4203)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      146503774..146536103 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255567.1 → XP_030111427.1  transmembrane 7 superfamily member 3 isoform X1

      Conserved Domains (1) summary
      pfam13886
      Location:79 → 286
      DUF4203; Domain of unknown function (DUF4203)

    2. XM_036152277.1 → XP_036008170.1  transmembrane 7 superfamily member 3 isoform X1

      Conserved Domains (1) summary
      pfam13886
      Location:79 → 286
      DUF4203; Domain of unknown function (DUF4203)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CRG1.2 GenPept UniProtKB/Swiss-Prot:Q9CRG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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