Slc30a6 solute carrier family 30 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc30a6provided by RGD
Official Full Name: solute carrier family 30 member 6provided by RGD
Primary source: RGD:1309250
See related: EnsemblRapid:ENSRNOG00000005856 AllianceGenome:RGD:1309250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in regulation of zinc ion transport and zinc ion import into Golgi lumen. Predicted to act upstream of or within Golgi to endosome transport. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi apparatus. Orthologous to human SLC30A6 (solute carrier family 30 member 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Adrenal (RPKM 62.5), Kidney (RPKM 62.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (26772804..26802656, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (21020931..21050785, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (22197003..22226364, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
NOT enables zinc:proton antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Golgi to endosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of zinc ion transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into Golgi lumen	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc transporter 6

Names: solute carrier family 30 (zinc transporter), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277279.1 → NP_001264208.1 zinc transporter 6

See identical proteins and their annotated locations for NP_001264208.1

Status: VALIDATED

Source sequence(s)

BC167086, JAXUCZ010000006

UniProtKB/TrEMBL

A0A8J8YBF1, B2RZA8, F7FK99

Related

ENSRNOP00000007919.8, ENSRNOT00000007919.9

Conserved Domains (2) summary

COG1230
Location:55 → 331

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:43 → 255

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

26772804..26802656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111896.2 → XP_038967824.1 zinc transporter 6 isoform X1

UniProtKB/TrEMBL

A0A8I6ABZ0

Conserved Domains (1) summary

COG1230
Location:6 → 282

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]
XM_063261613.1 → XP_063117683.1 zinc transporter 6 isoform X2
XM_039111898.2 → XP_038967826.1 zinc transporter 6 isoform X3

Conserved Domains (1) summary

COG1230
Location:51 → 180

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106708.1: Suppressed sequence

Description

NM_001106708.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.