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    Lrrc57 leucine rich repeat containing 57 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311346, updated on 28-Oct-2024

    Summary

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    Symbol
    Lrrc57provided by RGD
    Full Name
    leucine rich repeat containing 57provided by RGD
    Primary source
    RGD:1307128
    See related
    EnsemblRapid:ENSRNOG00000009143 AllianceGenome:RGD:1307128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307128
    Summary
    Predicted to be located in membrane. Orthologous to human LRRC57 (leucine rich repeat containing 57). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 149.8), Kidney (RPKM 85.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrrc57 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127998535..128007004, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107544786..107553256, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112365936..112371787, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene synaptosome associated protein 23 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene uncharacterized LOC120101914 Neighboring gene codanin 1 Neighboring gene tau tubulin kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109337

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 57
    Names
    leucine-rich repeat-containing protein 57-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012354.2 → NP_001012354.1  leucine-rich repeat-containing protein 57

      See identical proteins and their annotated locations for NP_001012354.1

      Status: VALIDATED

      Source sequence(s)
      BC089966, CV111644
      UniProtKB/Swiss-Prot
      Q5FVI3
      UniProtKB/TrEMBL
      A6HPK3, A6HPK4
      Conserved Domains (3) summary
      cd00116
      Location:23 → 191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:38 → 97
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127998535..128007004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234777.5 → XP_006234839.1  leucine-rich repeat-containing protein 57 isoform X1

      UniProtKB/TrEMBL
      A6HPK3
      Conserved Domains (3) summary
      cd00116
      Location:48 → 216
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:65 → 88
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:63 → 122
      LRR_8; Leucine rich repeat

    2. XM_006234778.4 → XP_006234840.1  leucine-rich repeat-containing protein 57 isoform X2

      See identical proteins and their annotated locations for XP_006234840.1

      UniProtKB/Swiss-Prot
      Q5FVI3
      UniProtKB/TrEMBL
      A6HPK3, A6HPK4
      Conserved Domains (3) summary
      cd00116
      Location:23 → 191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:38 → 97
      LRR_8; Leucine rich repeat

    3. XM_006234780.5 → XP_006234842.1  leucine-rich repeat-containing protein 57 isoform X3

      UniProtKB/TrEMBL
      A6HPK3
      Related
      ENSRNOP00000050922.6, ENSRNOT00000049756.7
      Conserved Domains (3) summary
      cd00116
      Location:65 → 233
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:82 → 105
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:80 → 139
      LRR_8; Leucine rich repeat

    4. XM_006234779.5 → XP_006234841.1  leucine-rich repeat-containing protein 57 isoform X2

      See identical proteins and their annotated locations for XP_006234841.1

      UniProtKB/Swiss-Prot
      Q5FVI3
      UniProtKB/TrEMBL
      A6HPK3, A6HPK4
      Conserved Domains (3) summary
      cd00116
      Location:23 → 191
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:40 → 63
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:38 → 97
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVI3.1 GenPept UniProtKB/Swiss-Prot:Q5FVI3

    Gene LinkOut

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