Mt1 metallothionein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mt1provided by RGD
Official Full Name: metallothionein 1provided by RGD
Primary source: RGD:3117
See related: EnsemblRapid:ENSRNOG00000025764 AllianceGenome:RGD:3117
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mt; Mt1a
Summary: Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to zinc ion. Predicted to be located in cytosol and lysosome. Predicted to be active in cytoplasm and nucleus. Biomarker of kidney failure; median neuropathy; and transient cerebral ischemia. Orthologous to human MT1A (metallothionein 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 2019.6), Testes (RPKM 875.9) and 6 other tissues See more
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Genomic context

Location:: 19p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10831959..10832975, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10826032..10827048, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (11301991..11303007, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway.
Title: MTIM affects retinal ganglion cells through PI3K/AKT signaling pathway.
The increased hepatic MT protein in diabetic rats was not associated with the metal levels, but was associated with the oxidative damage.
Title: Diabetes Mellitus induces alterations in metallothionein protein expression and metal levels in the testis and liver.
TBI in rats resulted in lower levels of MT1 and MT2; replication of these findings is necessary as is evaluation of the consequences of lower receptor levels.
Title: Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2.
Although,there is induction of metallothionein due to arsenic toxicity, the sequestration of arsenic(III) ions by metallothionein was not observed. Therefore, it can be concluded that the sequestration of arsenic by metallothionein in liver is not the mechanism for providing protection in case of acute arsenic toxicity unlike cadmium and other toxic heavy elements.
Title: Metallothionein does not sequester arsenic(III) ions in condition of acute arsenic toxicity.
acute attack of experimental autoimmune encephalomyelitis was followed by increased expression of metallothioneins in molecular and granular cell layer of hippocampus.
Title: Hippocampal expressions of metallothionein I/II and glycoprotein 96 in EAE-prone and EAE-resistant strains of rats.
An inhibitory effect of melatonin on oxytocin secretion from the rat hypothalamo-neurohypophysial system is mediated through a subtype MT1 membrane receptor and its action is independent of subtype MT2 receptor. However, for the stimulatory effect of pharmacological concentration of the pineal hormone on oxytocin release, probably mechanisms other than membrane MT1/MT2 receptor(s)-dependent are involved.
Title: The role of melatonin membrane receptors in melatonin-dependent oxytocin secretion from the rat hypothalamo-neurohypophysial system - an in vitro and in vivo approach.
After passing middle age we observe a huge increase in MT3 transcripts in both cortical and hippocampal areas, while the MT1/2 mRNA content increases slightly
Title: Age-related changes of metallothionein 1/2 and metallothionein 3 expression in rat brain.
The recurrent seizures plus normal diet group showed worse performances in neurological reflex tests and reduced latencies to myoclonic seizures induced by penicillin compared with the control, which was concomitant with altered expressions of ZnT-7, MT-1, MT-2, and ZIP7.
Title: Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions.
MT-I/II are required for the conditioning lesion effect and can promote axonal regeneration in the injured central nervous system.
Title: Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
These data indicate that maternal zinc deficiency resulted in an elevated incidence of fetal heart malformations, which was associated with significant decreases in placental MT-1 and ZnT-1 mRNA expressions
Title: Suppression of placental metallothionein 1 and zinc transporter 1 mRNA expressions contributes to fetal heart malformations caused by maternal zinc deficiency.

Submit: New GeneRIF Correction See all GeneRIFs (39)

General gene information

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Markers

PMC164851P1 (e-PCR)
- UniSTS:271521

D19Arb7 (e-PCR)
- UniSTS:240551

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to chromate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detoxification of copper ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular monoatomic cation homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: metallothionein-1

Names: MT-1; MT-I; metallothionein 1a; metallothionein-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.