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    OPRPN opiorphin prepropeptide [ Homo sapiens (human) ]

    Gene ID: 58503, updated on 28-Oct-2024

    Summary

    Official Symbol
    OPRPNprovided by HGNC
    Official Full Name
    opiorphin prepropeptideprovided by HGNC
    Primary source
    HGNC:HGNC:17279
    See related
    Ensembl:ENSG00000171199 MIM:608936; AllianceGenome:HGNC:17279
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BPLP; PRL1; PROL1; opiorphin
    Summary
    This gene encodes a member of the proline-rich protein family. The encoded protein has multiple proposed functions, including roles in pain suppression, penile erection, and protection of the eye surface. The QRFSR pentapeptide, known as opiorphin, is derived from the N-terminal of this protein. Opiorphin inhibits the enkephalin-inactivating peptidases neprilysin and aminopeptidase N, and this activity is thought to reduce sensitivity to painful stimuli by effecting enkephalin-related activation of opioid-dependent pathways. Opiorphin may also act as an anti-depressant. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
    Expression
    Restricted expression toward salivary gland (RPKM 9.7) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See OPRPN in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (70397940..70410195)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73737473..73749728)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71263657..71275912)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene submaxillary gland androgen regulated protein 3B Neighboring gene mucin 7, secreted Neighboring gene amelotin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    opiorphin prepropeptide
    Names
    basic proline-rich lacrimal protein
    basic proline-rich protein
    proline rich, lacrimal 1
    proline-rich 1
    proline-rich protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302807.2NP_001289736.1  opiorphin prepropeptide isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) lacks the functional QRFSR pentapeptide, known as opiorphin, located in the N-terminal of isoform 1.
      Source sequence(s)
      CD721906, CD722615, CD723077
      Conserved Domains (2) summary
      pfam14124
      Location:155
      DUF4291; Domain of unknown function (DUF4291)
      pfam15621
      Location:118
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
    2. NM_021225.5NP_067048.4  opiorphin prepropeptide isoform 1 precursor

      See identical proteins and their annotated locations for NP_067048.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC092438, CK430664
      Consensus CDS
      CCDS43235.1
      UniProtKB/Swiss-Prot
      A8MZ07, P85047, Q99935
      Related
      ENSP00000382485.2, ENST00000399575.7
      Conserved Domains (1) summary
      pfam15621
      Location:396
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    RNA

    1. NR_126503.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      CD721906, CD722615, CK429697

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      70397940..70410195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      73737473..73749728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)