Stmp1 short transmembrane mitochondrial protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stmp1provided by RGD
Official Full Name: short transmembrane mitochondrial protein 1provided by RGD
Primary source: RGD:1591053
See related: EnsemblRapid:ENSRNOG00000067332 AllianceGenome:RGD:1591053
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in mitochondrial respiratory chain complex assembly; positive regulation of NLRP3 inflammasome complex assembly; and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrial intermembrane space and mitochondrial outer membrane. Predicted to be part of respiratory chain complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human STMP1 (short transmembrane mitochondrial protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 338.5), Spleen (RPKM 333.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (64894663..64904495)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (63927523..63937355)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (62780596..62790428)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reports the identification by tandem mass spec of a novel protein, proteolipid with a mass of 5,283 Da, (PL-5283).
Title: Identification of membrane proteins by tandem mass spectrometry of protein ions.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134086 (e-PCR)
- UniSTS:217368

RH128184 (e-PCR)
- UniSTS:211492

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respirasome assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex III assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: short transmembrane mitochondrial protein 1

Names: PL-5283 protein; uncharacterized protein C7orf73 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195503.2 → NP_001182432.1 short transmembrane mitochondrial protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

M0R474

Conserved Domains (1) summary

pfam15054
Location:4 → 55

DUF4535; Domain of unknown function (DUF4535)
NM_001195504.2 → NP_001182433.1 short transmembrane mitochondrial protein 1 isoform 2

See identical proteins and their annotated locations for NP_001182433.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6IEN9

Related

ENSRNOP00000105706.1, ENSRNOT00000106740.2

Conserved Domains (1) summary

pfam15054
Location:4 → 44

DUF4535; Domain of unknown function (DUF4535)