AURKA aurora kinase A [Homo sapiens (human)] - Gene

Summary

Official Symbol: AURKAprovided by HGNC
Official Full Name: aurora kinase Aprovided by HGNC
Primary source: HGNC:HGNC:11393
See related: Ensembl:ENSG00000087586 MIM:603072; AllianceGenome:HGNC:11393
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIK; ARK1; AURA; BTAK; STK6; STK7; STK15; PPP1R47
Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 12.9), lymph node (RPKM 6.9) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (56369390..56392215, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (58146836..58169709, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (54944446..54967271, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features.
Title: Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features.
Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.
Title: Transcription Factor ETV4 Activates AURKA to Promote PD-L1 Expression and Mediate Immune Escape in Lung Adenocarcinoma.
Aurora Kinase A Is Overexpressed in Human Retinoblastoma and Correlates with Histopathologic High-Risk Factors: Implications for Targeted Therapy.
Title: Aurora Kinase A Is Overexpressed in Human Retinoblastoma and Correlates with Histopathologic High-Risk Factors: Implications for Targeted Therapy.
Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR-506-3p/AURKA axis.
Title: Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR-506-3p/AURKA axis.
Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid beta Protein Levels in Neurons.
Title: Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons.
SOX9 is regulated by AURKA in response to Helicobacter pylori infection via EIF4E-mediated cap-dependent translation.
Title: SOX9 is regulated by AURKA in response to Helicobacter pylori infection via EIF4E-mediated cap-dependent translation.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Title: AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERbeta.
Title: AURKA Enhances the Glycolysis and Development of Ovarian Endometriosis Through ERβ.
AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
Title: AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m[6]A-dependent stabilization of AURKA mRNA.
Title: The PIN1-YTHDF1 axis promotes breast tumorigenesis via the m(6)A-dependent stabilization of AURKA mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (666)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates AURKA in HeLa cells within 12 hours of exposure	PubMed
Vpu	vpu	In vitro protein-protein interaction analysis identifies a Vpu-binding host protein aurora kinase A (AURKA, AURA)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12027 (e-PCR)
- UniSTS:13896

RH80570 (e-PCR)
- UniSTS:84832

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-53807 (e-PCR)
- UniSTS:64439

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables protein serine/threonine/tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in anterior/posterior axis specification	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome localization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver regeneration	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in mitotic centrosome separation	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic nuclear division	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein localization to centrosome	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
involved_in regulation of centrosome cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in spindle assembly involved in female meiosis I	IEA Inferred from Electronic Annotation more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon hillock	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in centriole	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	TAS Traceable Author Statement more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in germinal vesicle	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in meiotic spindle	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	TAS Traceable Author Statement more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info
located_in mitotic spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in pronucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	TAS Traceable Author Statement more info	PubMed
colocalizes_with spindle microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole centrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: aurora kinase A

Names: aurora 2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; breast tumor-amplified kinase; protein phosphatase 1, regulatory subunit 47; serine/threonine protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A

NP_001310232.1

EC 2.7.11.1

NP_001310233.1

EC 2.7.11.1

NP_001310234.1

EC 2.7.11.1

NP_001411346.1

EC 2.7.11.1

NP_001411347.1

EC 2.7.11.1

NP_001411348.1

EC 2.7.11.1

NP_001411349.1

EC 2.7.11.1

NP_003591.2

EC 2.7.11.1

NP_940835.1

EC 2.7.11.1

NP_940836.1

EC 2.7.11.1

NP_940837.1

EC 2.7.11.1

NP_940838.1

EC 2.7.11.1

NP_940839.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012133.1 RefSeqGene

Range

5081..27906

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001323303.2 → NP_001310232.1 aurora kinase A isoform 1

Status: REVIEWED

Source sequence(s)

AF011468, AL121914, BP224535

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_001323304.2 → NP_001310233.1 aurora kinase A isoform 1

Status: REVIEWED

Source sequence(s)

BC001280, BP224535, BU171303

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000360407.2, ENST00000371356.6

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_001323305.2 → NP_001310234.1 aurora kinase A isoform 1

Status: REVIEWED

Source sequence(s)

AF011468, AL121914

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_001424417.1 → NP_001411346.1 aurora kinase A isoform 1

Status: REVIEWED

Source sequence(s)

AL121914

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5
NM_001424418.1 → NP_001411347.1 aurora kinase A isoform 2

Status: REVIEWED

Source sequence(s)

AL121914
NM_001424419.1 → NP_001411348.1 aurora kinase A isoform 2

Status: REVIEWED

Source sequence(s)

AL121914
NM_001424420.1 → NP_001411349.1 aurora kinase A isoform 2

Status: REVIEWED

Source sequence(s)

AL121914
NM_003600.4 → NP_003591.2 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_003591.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AF008551, AF011468, AL711075, BP224535

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000216911.2, ENST00000347343.6

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_198433.3 → NP_940835.1 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_940835.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-9 encode the same protein.

Source sequence(s)

AF008551, AF011468, AL711075, BC027464, BP224535, BU542363

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_198434.3 → NP_940836.1 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_940836.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AF008551, AF011468, BM458030, BP224535

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000379250.1, ENST00000395914.5

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_198435.3 → NP_940837.1 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_940837.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AF011468, BU171303

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000379249.3, ENST00000395913.7

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_198436.3 → NP_940838.1 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_940838.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-6 encode the same protein.

Source sequence(s)

AF011468, BQ435059, CB113289

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000321591.6, ENST00000312783.10

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase
NM_198437.3 → NP_940839.1 aurora kinase A isoform 1

See identical proteins and their annotated locations for NP_940839.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.

Source sequence(s)

AF008551, AF011468, BF029182, BP224535

Consensus CDS

CCDS13451.1

UniProtKB/Swiss-Prot

E1P5F9, O14965, O60445, O75873, Q9BQD6, Q9UPG5

UniProtKB/TrEMBL

B2R6Z3

Related

ENSP00000379251.3, ENST00000395915.8

Conserved Domains (1) summary

cd14116
Location:127 → 384

STKc_Aurora-A; Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase