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    Nisch nischarin [ Mus musculus (house mouse) ]

    Gene ID: 64652, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nischprovided by MGI
    Official Full Name
    nischarinprovided by MGI
    Primary source
    MGI:MGI:1928323
    See related
    Ensembl:ENSMUSG00000021910 AllianceGenome:MGI:1928323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I-1; edsn; 1200007D05Rik; 3202002H23Rik
    Summary
    Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 82.3), adrenal adult (RPKM 79.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nisch in Genome Data Viewer
    Location:
    14 B; 14 19.09 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30892885..30928783, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31170928..31206826, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148 Neighboring gene troponin C, cardiac/slow skeletal Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The integrin-binding protein Nischarin regulates cell migration by inhibiting PAK. Alahari SK, et al. EMBO J, 2004 Jul 21. PMID 15229651, Free PMC Article
    2. Nischarin as a functional imidazoline (I1) receptor. Zhang J, et al. FEBS Lett, 2006 May 29. PMID 16678176
    3. Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. Tanabe M, et al. Eur J Pharmacol, 2008 Jul 28. PMID 18602099
    4. IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain. Li S, et al. Biomed Pharmacother, 2022 Sep. PMID 36076473
    5. Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells. Lui TN, et al. Neurosci Lett, 2010 May 3. PMID 20298750

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contribution of Nischarin/IRAS in CNS development, injury and diseases.
      Title: Contribution of Nischarin/IRAS in CNS development, injury and diseases.
    2. Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
      Title: Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function.
    3. Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Delta5-6) Knockout Mouse Model.
      Title: Nischarin Deletion Reduces Oxidative Metabolism and Overall ATP: A Study Using a Novel NISCH(Δ5-6) Knockout Mouse Model.
    4. Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.
      Title: Expression of nischarin, an imidazoline 1 receptor candidate protein, in the ventrolateral medulla of newborn rats.
    5. These data suggest that IRAS/Nischarin may play an important role in the development of morphine tolerance and physical dependence in vivo through modulating MOR expression, as well as AMPA GluR1-S845 phosphorylation, which might be one of the mechanisms underlying the development of opiate addiction.
      Title: The role of IRAS/Nischarin involved in the development of morphine tolerance and physical dependence.
    6. results indicate that Nisch is an important AMPK inhibitor and a critical regulator of energy homeostasis, including lipid and glucose metabolism.
      Title: Nischarin inhibition alters energy metabolism by activating AMP-activated protein kinase.
    7. We identified a significant genetic interaction between Nisch and Itga5; mice heterozygous for Itga5-null and homozygous for edison mutations display a significantly increased penetrance and severity of chronic otitis media.
      Title: A mutation in Nischarin causes otitis media via LIMK1 and NF-κB pathways.
    8. Nischarin inhibits neurite outgrowth by blocking PAK1 activation in neurons.
      Title: Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity.
    9. Data from studies using various receptor antagonists/agonists suggest that imidazoline receptors (Nisch I-1), alpha2-adrenoceptors, and endothelin-A receptors are involved in body temperature regulation in mice.
      Title: Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
    10. Activation of I1-imidazoline receptor ameliorated energy intake and epididymal white adipose tissue accumulation.
      Title: Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nischarin
    Names
    I1R
    IR1
    imidazoline receptor 1
    imidazoline receptor I-1-like protein
    imidazoline-1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347583.1 → NP_001334512.1  nischarin isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons and includes an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154446, AK004628, AK160990, BY602009, CJ106892
      Consensus CDS
      CCDS84107.1
      UniProtKB/TrEMBL
      Q8CF63
      Related
      ENSMUSP00000132413.2, ENSMUST00000172142.8

    2. NM_022656.2 → NP_073147.2  nischarin isoform 1

      See identical proteins and their annotated locations for NP_073147.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154446, AK122412, BC089329, BP761152, CJ106892
      Consensus CDS
      CCDS36853.1
      UniProtKB/Swiss-Prot
      Q2YDV7, Q80TM9, Q8C354, Q8C4X9, Q8CBH0, Q91XW6, Q99LG6, Q9EPW8, Q9WUM6
      UniProtKB/TrEMBL
      B7ZN33
      Related
      ENSMUSP00000022469.7, ENSMUST00000022469.13
      Conserved Domains (5) summary
      cd06875
      Location:15 → 130
      PX_IRAS; The phosphoinositide binding Phox Homology domain of the Imidazoline Receptor Antisera-Selected
      cd00116
      Location:271 → 417
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:291 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:312 → 352
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:291 → 346
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30892885..30928783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158779.1 → XP_036014672.1  nischarin isoform X1

    2. XM_017316116.1 → XP_017171605.1  nischarin isoform X1

    3. XM_017316115.3 → XP_017171604.1  nischarin isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80TM9.2 GenPept UniProtKB/Swiss-Prot:Q80TM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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