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    Mfsd4b1 major facilitator superfamily domain containing 4B1 [ Mus musculus (house mouse) ]

    Gene ID: 215929, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mfsd4b1provided by MGI
    Official Full Name
    major facilitator superfamily domain containing 4B1provided by MGI
    Primary source
    MGI:MGI:2143575
    See related
    Ensembl:ENSMUSG00000038522 AllianceGenome:MGI:2143575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naglt1a
    Summary
    Predicted to enable D-glucose transmembrane transporter activity. Predicted to be involved in sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. Is expressed in urinary system. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 31.8), liver adult (RPKM 11.3) and 1 other tissue See more
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    Genomic context

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    See Mfsd4b1 in Genome Data Viewer
    Location:
    10 B1; 10 21.43 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (39877569..39901264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (40001573..40025268, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 4B3, pseudogene Neighboring gene neutrophil immunoglobulin-like receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E5125 Neighboring gene major facilitator superfamily domain containing 4B5 Neighboring gene STARR-seq mESC enhancer starr_26408 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 10 Neighboring gene STARR-seq mESC enhancer starr_26410 Neighboring gene predicted gene, 25613 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:39873206-39873472 Neighboring gene STARR-positive B cell enhancer ABC_E11435 Neighboring gene predicted gene, 31992

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25869

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent glucose transporter 1A
    Names
    major facilitator superfamily domain-containing protein 4B1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144821.4 → NP_659070.2  sodium-dependent glucose transporter 1A

      See identical proteins and their annotated locations for NP_659070.2

      Status: VALIDATED

      Source sequence(s)
      AC168279
      Consensus CDS
      CCDS35884.2
      UniProtKB/Swiss-Prot
      Q8VCV9
      Related
      ENSMUSP00000128324.3, ENSMUST00000163705.3
      Conserved Domains (2) summary
      cd06174
      Location:1 → 404
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      PRK03699
      Location:12 → 422
      PRK03699; putative transporter; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      39877569..39901264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512696.5 → XP_006512759.1  sodium-dependent glucose transporter 1A isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:1 → 339
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCV9.2 GenPept UniProtKB/Swiss-Prot:Q8VCV9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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