Eloa elongin A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eloaprovided by MGI
Official Full Name: elongin Aprovided by MGI
Primary source: MGI:MGI:1351315
See related: Ensembl:ENSMUSG00000028668 AllianceGenome:MGI:1351315
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tceb3; 110kDa; Tceb3a
Summary: Predicted to be involved in regulation of transcription by RNA polymerase II and transcription elongation by RNA polymerase II. Predicted to be located in site of DNA damage. Predicted to be part of elongin complex. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to several human genes including ELOA (elongin A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 13.4), liver E14 (RPKM 12.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 68.34 cM; 4 D3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135730681..135748960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136003370..136021649, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo.
Title: Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo.
Polycomb repressive complex 2 modulates transcription of a subset of low expression target genes in part via methylation of EloA.
Title: Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.
Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
Title: Transcriptional properties of mammalian elongin A and its role in stress response.
Elongin A transcriptional elongation activity, but not its E3 ubiquitin ligase activity, is critical for these functions.
Title: Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.
The authors that both the ubiquitylation and proteasomal degradation of the largest subunit of pol II (Rpb1) following UV-irradiation are significantly suppressed in Elongin A-deficient cells.
Title: Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.
a linkage between Elongin A function and cell cycle progression
Title: Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of elongin complex	IEA Inferred from Electronic Annotation more info
part_of elongin complex	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: elongin-A

Names: RNA polymerase II transcription factor SIII subunit A1; SIII p110; elongin 110 kDa subunit; transcription elongation factor B polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013736.4 → NP_038764.2 elongin-A

See identical proteins and their annotated locations for NP_038764.2

Status: PROVISIONAL

Source sequence(s)

AL672076

Consensus CDS

CCDS18798.1

UniProtKB/Swiss-Prot

Q3UI38, Q80VB2, Q8CB77, Q9R0Q5

Related

ENSMUSP00000030427.6, ENSMUST00000030427.6

Conserved Domains (2) summary

cd00183
Location:37 → 76

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

pfam06881
Location:565 → 663

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A