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    Frk fyn-related kinase [ Mus musculus (house mouse) ]

    Gene ID: 14302, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Frkprovided by MGI
    Official Full Name
    fyn-related kinaseprovided by MGI
    Primary source
    MGI:MGI:103265
    See related
    Ensembl:ENSMUSG00000019779 AllianceGenome:MGI:103265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BSK; GTK; RAK; BSK/IYK
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; innate immune response; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in large intestine adult (RPKM 4.3), placenta adult (RPKM 3.4) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Frk in Genome Data Viewer
    Location:
    10 B1; 10 18.85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (34359396..34487530)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (34483400..34611232)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26564 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:34017128-34017331 Neighboring gene TSPY-like 4 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26275 Neighboring gene collagen, type X, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_26277 Neighboring gene STARR-seq mESC enhancer starr_26278 Neighboring gene STARR-seq mESC enhancer starr_26279 Neighboring gene STARR-seq mESC enhancer starr_26280 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_26281 Neighboring gene STARR-seq mESC enhancer starr_26282 Neighboring gene STARR-seq mESC enhancer starr_26283 Neighboring gene STARR-seq mESC enhancer starr_26284 Neighboring gene survival motor neuron 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. iyk, a novel intracellular protein tyrosine kinase differentially expressed in the mouse mammary gland and intestine. Thuveson M, et al. Biochem Biophys Res Commun, 1995 Apr 17. PMID 7733928
    2. Cloning of BSK, a murine FRK homologue with a specific pattern of tissue distribution. Oberg-Welsh C, et al. Gene, 1995 Jan 23. PMID 7835707
    3. Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Chandrasekharan S, et al. Mol Cell Biol, 2002 Jul. PMID 12077350, Free PMC Article
    4. Role of Fyn tyrosine kinase in ethanol consumption by mice. Cowen MS, et al. Alcohol Clin Exp Res, 2003 Aug. PMID 12966312
    5. The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. Welsh M, et al. Biochem J, 2004 Aug 15. PMID 15186217, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions.
      Title: A role of FRK in regulation of embryonal pancreatic beta cell formation.
    2. The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
      Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
    3. Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Decreases in the circulating levels of T3 but not T4 are reminiscent of euthyroid sick syndrome, a stress-associated clinical condition
      Title: Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.
    4. Experiments with Fyn-deficient mice indicate that Fyn genotype does not influence ethanol consumption, neither under basal conditions nor following a deprivation period or stress.
      Title: Role of Fyn tyrosine kinase in ethanol consumption by mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase FRK
    Names
    B-cell src-homology tyrosine kinase
    beta-cell Src-homology tyrosine kinase
    intestine tyrosine kinase
    NP_001153016.1
    NP_001345698.1
    NP_034367.2
    XP_006512597.1
    XP_006512599.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159544.1 → NP_001153016.1  tyrosine-protein kinase FRK

      See identical proteins and their annotated locations for NP_001153016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK052614, AK164460, AK166379, BP761286, CN665865, L36132
      Consensus CDS
      CCDS23781.1
      UniProtKB/Swiss-Prot
      Q61364, Q61745, Q922K9
      Related
      ENSMUSP00000130289.2, ENSMUST00000170771.3
      Conserved Domains (3) summary
      cd10369
      Location:119 → 214
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:54 → 111
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:232 → 501
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    2. NM_001358769.1 → NP_001345698.1  tyrosine-protein kinase FRK

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AC153960, AK052614, AK164460, BP761286
      Consensus CDS
      CCDS23781.1
      UniProtKB/Swiss-Prot
      Q61364, Q61745, Q922K9
      Conserved Domains (3) summary
      cd10369
      Location:119 → 214
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:54 → 111
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:232 → 501
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    3. NM_010237.3 → NP_034367.2  tyrosine-protein kinase FRK

      See identical proteins and their annotated locations for NP_034367.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.
      Source sequence(s)
      AK028855, AK164460, AK166379, BP761286
      Consensus CDS
      CCDS23781.1
      UniProtKB/Swiss-Prot
      Q61364, Q61745, Q922K9
      Related
      ENSMUSP00000019913.8, ENSMUST00000019913.15
      Conserved Domains (3) summary
      cd10369
      Location:119 → 214
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:54 → 111
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:232 → 501
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      34359396..34487530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512534.5 → XP_006512597.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_006512597.1

      UniProtKB/Swiss-Prot
      Q61364, Q61745, Q922K9
      Conserved Domains (3) summary
      cd10369
      Location:119 → 214
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:54 → 111
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:232 → 501
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

    2. XM_006512536.5 → XP_006512599.1  tyrosine-protein kinase FRK isoform X1

      See identical proteins and their annotated locations for XP_006512599.1

      UniProtKB/Swiss-Prot
      Q61364, Q61745, Q922K9
      Conserved Domains (3) summary
      cd10369
      Location:119 → 214
      SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)
      cd11845
      Location:54 → 111
      SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases
      cd05068
      Location:232 → 501
      PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922K9.3 GenPept UniProtKB/Swiss-Prot:Q922K9

    Gene LinkOut

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