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Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

Gene ID: 11789, updated on 5-Nov-2024

Summary

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Official Symbol: Apcprovided by MGI
Official Full Name: APC, WNT signaling pathway regulatorprovided by MGI
Primary source: MGI:MGI:88039
See related: Ensembl:ENSMUSG00000005871 AllianceGenome:MGI:88039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CC1; Min; mAPC
Summary: Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation; regionalization; and regulation of apoptotic process. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and peripheral nervous system ganglion. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial adenomatous polyposis 1; gastrointestinal system cancer (multiple); hereditary desmoid disease; and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

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See Apc in Genome Data Viewer

Location:: 18 B1; 18 18.53 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34353350..34455243)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34220297..34322190)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC[Min/+] Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-kappaB Signaling Pathway.
Title: Plasma-Derived Extracellular Vesicles and Non-Extracellular Vesicle Components from APC(Min/+) Mice Promote Pro-Tumorigenic Activities and Activate Human Colonic Fibroblasts via the NF-κB Signaling Pathway.
Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
Title: Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
Title: Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
Title: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
Title: Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
Title: Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
LAT1 expression influences Paneth cell number and tumor development in Apc[Min/+] mice.
Title: LAT1 expression influences Paneth cell number and tumor development in Apc(Min/+) mice.
Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
Title: Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
Title: USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
Title: HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (230)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (8)
Gene trapped (1)
Targeted (27) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Apc (e-PCR), detects polymorphism
- UniSTS:532262

Apc (e-PCR), detects polymorphism
- UniSTS:141101

Apc (e-PCR), detects polymorphism
- UniSTS:141102

Apc (e-PCR), detects polymorphism
- UniSTS:141103

Apc (e-PCR), detects polymorphism
- UniSTS:141104

Apc (e-PCR), detects polymorphism
- UniSTS:141105

PMC122454P1 (e-PCR)
- UniSTS:270391

RH136516 (e-PCR)
- UniSTS:210498

D18Ertd734e (e-PCR), detects polymorphism
- UniSTS:167243

RH138935 (e-PCR)
- UniSTS:221021

AW124434 (e-PCR)
- UniSTS:181093

Apc (e-PCR), detects polymorphism
- UniSTS:256651

RH136329 (e-PCR)
- UniSTS:210319

RH135850 (e-PCR)
- UniSTS:209848

UniSTS:237769 (e-PCR)
- UniSTS:237769

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISS Inferred from Sequence or Structural Similarity more info
enables dynein complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of acinar cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of acinar cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosome organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytoplasmic microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of acinar cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of acinar cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nitrogen cycle metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of odontogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pattern specification process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of microtubule polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to centrosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within proximal/distal pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule-based process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Scrib-APC-beta-catenin complex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with adherens junction	ISO Inferred from Sequence Orthology more info
colocalizes_with adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin destruction complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin destruction complex	ISS Inferred from Sequence or Structural Similarity more info
part_of beta-catenin destruction complex	NAS Non-traceable Author Statement more info	PubMed
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell body fiber	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenomatous polyposis coli protein

Names: adenomatosis polyposis coli; multiple intestinal neoplasia

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360979.1 → NP_001347908.1 adenomatous polyposis coli protein isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC090534, AC114003, AL591373

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:588 → 628

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:404 → 447

ARM; armadillo repeat [structural motif]

pfam00514
Location:630 → 668

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1576 → 1599

APC_r; APC repeat

pfam05924
Location:1973 → 1992

SAMP; SAMP Motif

pfam05937
Location:2611 → 2783

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2164 → 2509

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:671 → 958

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:975 → 1074

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1222 → 1308

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1601 → 1654

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1685 → 1778

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1812 → 1886

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:332 → 405

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001360980.1 → NP_001347909.1 adenomatous polyposis coli protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC090534, AC114003, AL591373

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (16) summary

smart00185
Location:665 → 705

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:579 → 611

ARM; armadillo repeat [structural motif]

pfam00514
Location:707 → 745

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1653 → 1676

APC_r; APC repeat

pfam05924
Location:2050 → 2069

SAMP; SAMP Motif

pfam05937
Location:2688 → 2860

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2241 → 2586

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:748 → 1035

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1052 → 1151

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1299 → 1385

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1678 → 1731

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1762 → 1855

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1889 → 1963

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:391 → 464

APC_rep; Adenomatous polyposis coli (APC) repeat
NM_001402727.1 → NP_001389656.1 adenomatous polyposis coli protein isoform 1

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402728.1 → NP_001389657.1 adenomatous polyposis coli protein isoform 2

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402729.1 → NP_001389658.1 adenomatous polyposis coli protein isoform 2

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402730.1 → NP_001389659.1 adenomatous polyposis coli protein isoform 2

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402731.1 → NP_001389660.1 adenomatous polyposis coli protein isoform 3

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373

UniProtKB/TrEMBL

B2RUG9
NM_001402732.1 → NP_001389661.1 adenomatous polyposis coli protein isoform 4

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402733.1 → NP_001389662.1 adenomatous polyposis coli protein isoform 5

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402734.1 → NP_001389663.1 adenomatous polyposis coli protein isoform 6

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402735.1 → NP_001389664.1 adenomatous polyposis coli protein isoform 6

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402736.1 → NP_001389665.1 adenomatous polyposis coli protein isoform 7

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402737.1 → NP_001389666.1 adenomatous polyposis coli protein isoform 11

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402738.1 → NP_001389667.1 adenomatous polyposis coli protein isoform 8

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_001402739.1 → NP_001389668.1 adenomatous polyposis coli protein isoform 9

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373

Related

ENSMUSP00000111447.4, ENSMUST00000115781.10
NM_001402740.1 → NP_001389669.1 adenomatous polyposis coli protein isoform 10

Status: VALIDATED

Source sequence(s)

AC090534, AC114003, AL591373
NM_007462.4 → NP_031488.2 adenomatous polyposis coli protein isoform 3

See identical proteins and their annotated locations for NP_031488.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AC090534, AC114003, AL591373

Consensus CDS

CCDS29125.1

UniProtKB/Swiss-Prot

Q61315, Q62044

UniProtKB/TrEMBL

B2RUG9

Related

ENSMUSP00000078337.6, ENSMUST00000079362.13

Conserved Domains (16) summary

smart00185
Location:647 → 687

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:463 → 506

ARM; armadillo repeat [structural motif]

pfam00514
Location:689 → 727

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1635 → 1658

APC_r; APC repeat

pfam05924
Location:2032 → 2051

SAMP; SAMP Motif

pfam05937
Location:2670 → 2842

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2223 → 2568

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:730 → 1017

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1034 → 1133

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1281 → 1367

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1660 → 1713

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1744 → 1837

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1871 → 1945

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:391 → 464

APC_rep; Adenomatous polyposis coli (APC) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

34353350..34455243

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525529.4 → XP_006525592.1 adenomatous polyposis coli protein isoform X1

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:675 → 715

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:589 → 621

ARM; armadillo repeat [structural motif]

pfam00514
Location:717 → 755

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1663 → 1686

APC_r; APC repeat

pfam05924
Location:2060 → 2079

SAMP; SAMP Motif

pfam05937
Location:2698 → 2870

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2251 → 2596

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:758 → 1045

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1062 → 1161

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1309 → 1395

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1688 → 1741

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1772 → 1865

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1899 → 1973

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:401 → 474

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006525538.4 → XP_006525601.1 adenomatous polyposis coli protein isoform X15

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:574 → 614

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:488 → 520

ARM; armadillo repeat [structural motif]

pfam00514
Location:616 → 654

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1562 → 1585

APC_r; APC repeat

pfam05924
Location:1959 → 1978

SAMP; SAMP Motif

pfam05937
Location:2597 → 2769

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2150 → 2495

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:657 → 944

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:961 → 1060

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1208 → 1294

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1587 → 1640

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1671 → 1764

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1798 → 1872

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:315 → 373

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006525534.4 → XP_006525597.1 adenomatous polyposis coli protein isoform X6

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:640 → 680

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:554 → 586

ARM; armadillo repeat [structural motif]

pfam00514
Location:682 → 720

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1628 → 1651

APC_r; APC repeat

pfam05924
Location:2025 → 2044

SAMP; SAMP Motif

pfam05937
Location:2663 → 2835

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2216 → 2561

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:723 → 1010

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1027 → 1126

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1274 → 1360

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1653 → 1706

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1737 → 1830

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1864 → 1938

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:366 → 439

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_036160948.1 → XP_036016841.1 adenomatous polyposis coli protein isoform X21

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:539 → 579

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:453 → 485

ARM; armadillo repeat [structural motif]

pfam00514
Location:581 → 621

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1527 → 1550

APC_r; APC repeat

pfam05924
Location:1924 → 1943

SAMP; SAMP Motif

pfam05937
Location:2562 → 2734

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2115 → 2460

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:622 → 909

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:926 → 1025

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1173 → 1259

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1552 → 1605

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1636 → 1729

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1763 → 1837

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:280 → 338

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_036160950.1 → XP_036016843.1 adenomatous polyposis coli protein isoform X24

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:521 → 561

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:337 → 380

ARM; armadillo repeat [structural motif]

pfam00514
Location:563 → 603

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1509 → 1532

APC_r; APC repeat

pfam05924
Location:1906 → 1925

SAMP; SAMP Motif

pfam05937
Location:2544 → 2716

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2097 → 2442

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:604 → 891

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:908 → 1007

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1155 → 1241

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1534 → 1587

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1618 → 1711

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1745 → 1819

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:280 → 338

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250280.1 → XP_030106140.1 adenomatous polyposis coli protein isoform X9

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:622 → 662

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:438 → 481

ARM; armadillo repeat [structural motif]

pfam00514
Location:664 → 702

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1610 → 1633

APC_r; APC repeat

pfam05924
Location:2007 → 2026

SAMP; SAMP Motif

pfam05937
Location:2645 → 2817

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2198 → 2543

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:705 → 992

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1009 → 1108

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1256 → 1342

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1635 → 1688

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1719 → 1812

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1846 → 1920

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:366 → 439

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_036160951.1 → XP_036016844.1 adenomatous polyposis coli protein isoform X25

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (16) summary

smart00185
Location:511 → 551

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:327 → 370

ARM; armadillo repeat [structural motif]

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:553 → 593

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1499 → 1522

APC_r; APC repeat

pfam05924
Location:1896 → 1915

SAMP; SAMP Motif

pfam05937
Location:2534 → 2706

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2087 → 2432

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:594 → 881

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:898 → 997

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1145 → 1231

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1524 → 1577

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1608 → 1701

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1735 → 1809

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:270 → 328

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006525539.4 → XP_006525602.1 adenomatous polyposis coli protein isoform X20

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (16) summary

smart00185
Location:546 → 586

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:362 → 405

ARM; armadillo repeat [structural motif]

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:588 → 628

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1534 → 1557

APC_r; APC repeat

pfam05924
Location:1931 → 1950

SAMP; SAMP Motif

pfam05937
Location:2569 → 2741

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2122 → 2467

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:629 → 916

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:933 → 1032

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1180 → 1266

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1559 → 1612

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1643 → 1736

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1770 → 1844

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:305 → 363

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250281.2 → XP_030106141.1 adenomatous polyposis coli protein isoform X10

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (16) summary

smart00185
Location:612 → 652

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:428 → 471

ARM; armadillo repeat [structural motif]

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:654 → 694

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1600 → 1623

APC_r; APC repeat

pfam05924
Location:1997 → 2016

SAMP; SAMP Motif

pfam05937
Location:2635 → 2807

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2188 → 2533

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:695 → 982

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:999 → 1098

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1246 → 1332

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1625 → 1678

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1709 → 1802

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1836 → 1910

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:356 → 429

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250288.1 → XP_030106148.1 adenomatous polyposis coli protein isoform X16

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:571 → 611

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:485 → 517

ARM; armadillo repeat [structural motif]

pfam00514
Location:613 → 651

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1559 → 1582

APC_r; APC repeat

pfam05924
Location:1956 → 1975

SAMP; SAMP Motif

pfam05937
Location:2594 → 2766

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2147 → 2492

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:654 → 941

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:958 → 1057

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1205 → 1291

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1584 → 1637

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1668 → 1761

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1795 → 1869

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:297 → 370

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250283.1 → XP_030106143.1 adenomatous polyposis coli protein isoform X12

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:606 → 646

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:520 → 552

ARM; armadillo repeat [structural motif]

pfam00514
Location:648 → 688

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1594 → 1617

APC_r; APC repeat

pfam05924
Location:1991 → 2010

SAMP; SAMP Motif

pfam05937
Location:2629 → 2801

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2182 → 2527

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:689 → 976

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:993 → 1092

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1240 → 1326

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1619 → 1672

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1703 → 1796

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1830 → 1904

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:332 → 405

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_036160952.1 → XP_036016845.1 adenomatous polyposis coli protein isoform X26

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:487 → 527

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:303 → 346

ARM; armadillo repeat [structural motif]

pfam00514
Location:529 → 569

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1475 → 1498

APC_r; APC repeat

pfam05924
Location:1872 → 1891

SAMP; SAMP Motif

pfam05937
Location:2510 → 2682

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2063 → 2408

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:570 → 857

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:874 → 973

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1121 → 1207

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1500 → 1553

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1584 → 1677

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1711 → 1785

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:246 → 304

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250278.2 → XP_030106138.1 adenomatous polyposis coli protein isoform X7

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (16) summary

smart00185
Location:630 → 670

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:544 → 576

ARM; armadillo repeat [structural motif]

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam00514
Location:672 → 712

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1618 → 1641

APC_r; APC repeat

pfam05924
Location:2015 → 2034

SAMP; SAMP Motif

pfam05937
Location:2653 → 2825

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2206 → 2551

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:713 → 1000

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1017 → 1116

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1264 → 1350

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1643 → 1696

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1727 → 1820

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1854 → 1928

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:356 → 429

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250291.1 → XP_030106151.1 adenomatous polyposis coli protein isoform X18

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:556 → 596

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:372 → 415

ARM; armadillo repeat [structural motif]

pfam00514
Location:598 → 636

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1544 → 1567

APC_r; APC repeat

pfam05924
Location:1941 → 1960

SAMP; SAMP Motif

pfam05937
Location:2579 → 2751

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2132 → 2477

APC_basic; APC basic domain

pfam11414
Location:135 → 215

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:639 → 926

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:943 → 1042

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1190 → 1276

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1569 → 1622

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1653 → 1746

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1780 → 1854

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:315 → 373

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_036160946.1 → XP_036016839.1 adenomatous polyposis coli protein isoform X12

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:606 → 646

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:520 → 552

ARM; armadillo repeat [structural motif]

pfam00514
Location:648 → 688

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1594 → 1617

APC_r; APC repeat

pfam05924
Location:1991 → 2010

SAMP; SAMP Motif

pfam05937
Location:2629 → 2801

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2182 → 2527

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:689 → 976

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:993 → 1092

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1240 → 1326

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1619 → 1672

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1703 → 1796

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1830 → 1904

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:332 → 405

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250293.2 → XP_030106153.1 adenomatous polyposis coli protein isoform X22

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (17) summary

smart00185
Location:529 → 569

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:443 → 475

ARM; armadillo repeat [structural motif]

pfam00514
Location:571 → 609

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1517 → 1540

APC_r; APC repeat

pfam05924
Location:1914 → 1933

SAMP; SAMP Motif

pfam05937
Location:2552 → 2724

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2105 → 2450

APC_basic; APC basic domain

pfam11414
Location:125 → 205

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:612 → 899

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:916 → 1015

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1163 → 1249

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1542 → 1595

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1626 → 1719

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1753 → 1827

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam16689
Location:4 → 55

APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain

pfam18797
Location:270 → 328

APC_rep; Adenomatous polyposis coli (APC) repeat

cl00755
Location:172 → 296

zf-dskA_traR; Prokaryotic dksA/traR C4-type zinc finger
XM_030250282.2 → XP_030106142.1 adenomatous polyposis coli protein isoform X11

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:610 → 650

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:524 → 556

ARM; armadillo repeat [structural motif]

pfam00514
Location:652 → 690

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1598 → 1621

APC_r; APC repeat

pfam05924
Location:1995 → 2014

SAMP; SAMP Motif

pfam05937
Location:2633 → 2805

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2186 → 2531

APC_basic; APC basic domain

pfam11414
Location:105 → 185

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:693 → 980

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:997 → 1096

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1244 → 1330

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1623 → 1676

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1707 → 1800

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1834 → 1908

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:336 → 409

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006525533.4 → XP_006525596.1 adenomatous polyposis coli protein isoform X5

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:645 → 685

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:559 → 591

ARM; armadillo repeat [structural motif]

pfam00514
Location:687 → 725

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1633 → 1656

APC_r; APC repeat

pfam05924
Location:2030 → 2049

SAMP; SAMP Motif

pfam05937
Location:2668 → 2840

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2221 → 2566

APC_basic; APC basic domain

pfam11414
Location:105 → 185

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:728 → 1015

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:1032 → 1131

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1279 → 1365

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1658 → 1711

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1742 → 1835

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1869 → 1943

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:371 → 444

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250289.2 → XP_030106149.1 adenomatous polyposis coli protein isoform X16

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:571 → 611

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:485 → 517

ARM; armadillo repeat [structural motif]

pfam00514
Location:613 → 651

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1559 → 1582

APC_r; APC repeat

pfam05924
Location:1956 → 1975

SAMP; SAMP Motif

pfam05937
Location:2594 → 2766

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2147 → 2492

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:654 → 941

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:958 → 1057

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1205 → 1291

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1584 → 1637

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1668 → 1761

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1795 → 1869

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:297 → 370

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_006525536.5 → XP_006525599.1 adenomatous polyposis coli protein isoform X12

See identical proteins and their annotated locations for XP_006525599.1

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:606 → 646

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:520 → 552

ARM; armadillo repeat [structural motif]

pfam00514
Location:648 → 688

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1594 → 1617

APC_r; APC repeat

pfam05924
Location:1991 → 2010

SAMP; SAMP Motif

pfam05937
Location:2629 → 2801

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2182 → 2527

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:689 → 976

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:993 → 1092

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1240 → 1326

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1619 → 1672

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1703 → 1796

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1830 → 1904

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:332 → 405

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250292.2 → XP_030106152.1 adenomatous polyposis coli protein isoform X19

UniProtKB/TrEMBL

E9QLQ9

Conserved Domains (15) summary

smart00185
Location:553 → 593

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:369 → 412

ARM; armadillo repeat [structural motif]

pfam00514
Location:595 → 633

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1541 → 1564

APC_r; APC repeat

pfam05924
Location:1938 → 1957

SAMP; SAMP Motif

pfam05937
Location:2576 → 2748

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2129 → 2474

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:636 → 923

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:940 → 1039

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1187 → 1273

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1566 → 1619

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1650 → 1743

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1777 → 1851

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:297 → 370

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250284.2 → XP_030106144.1 adenomatous polyposis coli protein isoform X12

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:606 → 646

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:520 → 552

ARM; armadillo repeat [structural motif]

pfam00514
Location:648 → 688

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1594 → 1617

APC_r; APC repeat

pfam05924
Location:1991 → 2010

SAMP; SAMP Motif

pfam05937
Location:2629 → 2801

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2182 → 2527

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:689 → 976

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:993 → 1092

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1240 → 1326

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1619 → 1672

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1703 → 1796

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1830 → 1904

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:332 → 405

APC_rep; Adenomatous polyposis coli (APC) repeat
XM_030250295.2 → XP_030106155.1 adenomatous polyposis coli protein isoform X26

UniProtKB/Swiss-Prot

Q61315, Q62044

Conserved Domains (15) summary

smart00185
Location:487 → 527

ARM; Armadillo/beta-catenin-like repeats

sd00043
Location:303 → 346

ARM; armadillo repeat [structural motif]

pfam00514
Location:529 → 569

Arm; Armadillo/beta-catenin-like repeat

pfam05923
Location:1475 → 1498

APC_r; APC repeat

pfam05924
Location:1872 → 1891

SAMP; SAMP Motif

pfam05937
Location:2510 → 2682

EB1_binding; EB-1 Binding Domain

pfam05956
Location:2063 → 2408

APC_basic; APC basic domain

pfam11414
Location:66 → 146

Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein

pfam16629
Location:570 → 857

Arm_APC_u3; Armadillo-associated region on APC

pfam16630
Location:874 → 973

APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs

pfam16633
Location:1121 → 1207

APC_u9; Unstructured region on APC between 1st two creatine-rich regions

pfam16634
Location:1500 → 1553

APC_u13; Unstructured region on APC between APC_crr and SAMP

pfam16635
Location:1584 → 1677

APC_u14; Unstructured region on APC between SAMP and APC_crr

pfam16636
Location:1711 → 1785

APC_u15; Unstructured region on APC between APC_crr regions 5 and 6

pfam18797
Location:246 → 304

APC_rep; Adenomatous polyposis coli (APC) repeat