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    Tspan32 tetraspanin 32 [ Mus musculus (house mouse) ]

    Gene ID: 27027, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tspan32provided by MGI
    Official Full Name
    tetraspanin 32provided by MGI
    Primary source
    MGI:MGI:1350360
    See related
    Ensembl:ENSMUSG00000000244 AllianceGenome:MGI:1350360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Art-1; Phemx; Tssc6; D7Wsu37e
    Summary
    Acts upstream of or within several processes, including defense response to protozoan; integrin-mediated signaling pathway; and negative regulation of leukocyte activation. Located in cell surface. Part of integrin alphaIIb-beta3 complex. Is expressed in several structures, including central nervous system; ganglia; immune system; placenta; and tongue. Orthologous to human TSPAN32 (tetraspanin 32). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 20.5), liver E14.5 (RPKM 17.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan32 in Genome Data Viewer
    Location:
    7 F5; 7 88.09 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142558644..142573223)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143004907..143019486)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tyrosine hydroxylase Neighboring gene achaete-scute family bHLH transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E4987 Neighboring gene STARR-positive B cell enhancer ABC_E6616 Neighboring gene expressed sequence R74862 Neighboring gene STARR-seq mESC enhancer starr_20520 Neighboring gene STARR-positive B cell enhancer ABC_E6617 Neighboring gene STARR-seq mESC enhancer starr_20521 Neighboring gene nonconserved acetylation island sequence M93 enhancer Neighboring gene CD81 antigen Neighboring gene tumor-suppressing subchromosomal transferable fragment 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses. Tarrant JM, et al. Mol Cell Biol, 2002 Jul. PMID 12077330, Free PMC Article
    2. The gene trap resource: a treasure trove for hemopoiesis research. Forrai A, et al. Exp Hematol, 2005 Aug. PMID 16038776
    3. A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. Harada Y, et al. Biochem Biophys Res Commun, 2001 Jun 15. PMID 11396961
    4. TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN. Qiu Q, et al. Signal Transduct Target Ther, 2023 Mar 1. PMID 36854750, Free PMC Article
    5. A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets. Makkawi M, et al. Thromb Res, 2018 Jan. PMID 29178985

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
      Title: TSPAN32 suppresses chronic myeloid leukemia pathogenesis and progression by stabilizing PTEN.
    2. Study demonstrates a complementary role between TSSC6 and P2Y12 receptor in platelets in regulating 'outside in' integrin alphaIIbbeta3 signalling thrombus growth and stability.
      Title: A complementary role for tetraspanin superfamily member TSSC6 and ADP purinergic P2Y(12) receptor in platelets.
    3. The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
      Title: The absence of Tssc6, a member of the tetraspanin superfamily, does not affect lymphoid development but enhances in vitro T-cell proliferative responses.
    4. absence of platelet TSSC6 affects the secondary stability of arterial thrombi in vivo upon vascular injury
      Title: Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to protozoan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within hemostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of myeloid dendritic cell activation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to virus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin alphaIIb-beta3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-32
    Names
    AML1-regulated transmembrane protein 1
    pan hematopoietic expression
    protein Phemx
    tspan-32
    tumor-suppressing subchromosomal transferable fragment 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128080.2 → NP_001121552.1  tetraspanin-32 isoform a

      See identical proteins and their annotated locations for NP_001121552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AY039000
      Consensus CDS
      CCDS52459.1
      UniProtKB/Swiss-Prot
      Q923G9, Q9ESH0, Q9JHH2, Q9JHQ9, Q9JHR0, Q9JHR1, Q9JHR2, Q9JHS8
      Related
      ENSMUSP00000009396.7, ENSMUST00000009396.13
      Conserved Domains (2) summary
      cd03153
      Location:113 → 228
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 223
      Tetraspannin; Tetraspanin family

    2. NM_001128081.1 → NP_001121553.1  tetraspanin-32 isoform c

      See identical proteins and their annotated locations for NP_001121553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AJ279792, BY208601
      Consensus CDS
      CCDS52460.1
      UniProtKB/TrEMBL
      Q7TNQ7
      Related
      ENSMUSP00000080668.6, ENSMUST00000082008.12
      Conserved Domains (1) summary
      cd03153
      Location:86 → 173
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

    3. NM_001128082.1 → NP_001121554.1  tetraspanin-32 isoform d

      See identical proteins and their annotated locations for NP_001121554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (d) is shorter at the N-terminus and lacks two alternate internal segment compared to isoform a.
      Source sequence(s)
      AJ279794, BY208601
      Consensus CDS
      CCDS52461.1
      UniProtKB/TrEMBL
      G3X9S3
      Related
      ENSMUSP00000101543.2, ENSMUST00000105923.8
      Conserved Domains (1) summary
      cl02781
      Location:47 → 139
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    4. NM_020286.3 → NP_064682.1  tetraspanin-32 isoform b

      See identical proteins and their annotated locations for NP_064682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AF291425, BY208601
      Consensus CDS
      CCDS22037.1
      UniProtKB/TrEMBL
      D3Z0S2, Q3U3L6
      Related
      ENSMUSP00000074667.6, ENSMUST00000075172.12
      Conserved Domains (1) summary
      cd03153
      Location:86 → 201
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      142558644..142573223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508624.4 → XP_006508687.1  tetraspanin-32 isoform X6

      Conserved Domains (2) summary
      cd03153
      Location:128 → 191
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 171
      Tetraspannin; Tetraspanin family

    2. XM_006508620.4 → XP_006508683.1  tetraspanin-32 isoform X2

      Conserved Domains (2) summary
      cd03153
      Location:128 → 210
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 171
      Tetraspannin; Tetraspanin family

    3. XM_006508625.4 → XP_006508688.1  tetraspanin-32 isoform X7

      Conserved Domains (1) summary
      cd03153
      Location:74 → 166
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...

    4. XM_006508619.4 → XP_006508682.1  tetraspanin-32 isoform X1

      Conserved Domains (2) summary
      cd03153
      Location:128 → 238
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 171
      Tetraspannin; Tetraspanin family

    5. XM_006508622.4 → XP_006508685.1  tetraspanin-32 isoform X4

      Conserved Domains (2) summary
      cd03153
      Location:113 → 200
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:11 → 161
      Tetraspannin; Tetraspanin family

    6. XM_006508623.4 → XP_006508686.1  tetraspanin-32 isoform X5

      Conserved Domains (1) summary
      cl02781
      Location:74 → 194
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...

    7. XM_006508621.4 → XP_006508684.1  tetraspanin-32 isoform X3

      UniProtKB/TrEMBL
      D3Z0S2
      Related
      ENSMUSP00000115344.2, ENSMUST00000143512.3
      Conserved Domains (1) summary
      cd03153
      Location:94 → 203
      PHEMX_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHH2.2 GenPept UniProtKB/Swiss-Prot:Q9JHH2

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