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    Pi16 peptidase inhibitor 16 [ Mus musculus (house mouse) ]

    Gene ID: 74116, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Pi16provided by MGI
    Official Full Name
    peptidase inhibitor 16provided by MGI
    Primary source
    MGI:MGI:1921366
    See related
    Ensembl:ENSMUSG00000024011 AllianceGenome:MGI:1921366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cripi; PI-16; 1200009H11Rik
    Summary
    Predicted to enable peptidase inhibitor activity. Acts upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Located in extracellular space. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and neural retina. Orthologous to human PI16 (peptidase inhibitor 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 160.4), mammary gland adult (RPKM 72.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pi16 in Genome Data Viewer
    Location:
    17 A3.3; 17 15.22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29537770..29547876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29318796..29328903)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence BC004004 Neighboring gene predicted gene, 53222 Neighboring gene predicted pseudogene 10045 Neighboring gene predicted gene, 46603 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29469332-29469441 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29475389-29475661 Neighboring gene mitochondrial carrier 1 Neighboring gene STARR-positive B cell enhancer ABC_E4202 Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene FYVE, RhoGEF and PH domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function. Sun Y, et al. J Transl Med, 2024 Apr 2. PMID 38566233, Free PMC Article
    2. The fibroblast-derived protein PI16 controls neuropathic pain. Singhmar P, et al. Proc Natl Acad Sci U S A, 2020 Mar 10. PMID 32079726, Free PMC Article
    3. Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206(+) myeloid cells. Garrity R, et al. Brain Behav Immun, 2023 Aug. PMID 37315702, Free PMC Article
    4. Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. Regn M, et al. J Mol Cell Cardiol, 2016 Oct. PMID 27539859
    5. A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart. Frost RJ, et al. Circulation, 2007 Oct 16. PMID 17909105

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function.
      Title: Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function.
    2. Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
      Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
    3. Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
      Title: Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts.
    4. these findings support a model in which PI16 promotes neuropathic pain by mediating a cross-talk between fibroblasts and the endothelial barrier leading to barrier opening, cellular influx, and increased pain
      Title: The fibroblast-derived protein PI16 controls neuropathic pain.
    5. our data indicate that PI16 suppresses chemerin activation in the myocardium and suggest that this circuit may be part of the cardiac stress response.
      Title: Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.
    6. PI16, a novel protein secreted from the heart, is strongly upregulated early in heart failure and inhibits growth of cardiomyocytes both in vitro and in vivo
      Title: A secretion trap screen in yeast identifies protease inhibitor 16 as a novel antihypertrophic protein secreted from the heart.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidase inhibitor 16
    Names
    cysteine-rich protease inhibitor
    protease inhibitor 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023734.3 → NP_076223.3  peptidase inhibitor 16 precursor

      Status: VALIDATED

      Source sequence(s)
      AB046537, AI587910, AK157854
      Consensus CDS
      CCDS28595.2
      UniProtKB/Swiss-Prot
      Q148Q6, Q8CHU4, Q9ET66, Q9JJ56
      Related
      ENSMUSP00000110349.3, ENSMUST00000114701.10
      Conserved Domains (1) summary
      cd05559
      Location:35 → 168
      SCP_HrTT-1; SCP_HrTT-1: SCP-like extracellular protein domain in HrTT-1, a tail-tip epidermis marker in ascidians. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      29537770..29547876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525014.2 → XP_006525077.1  peptidase inhibitor 16 isoform X1

      UniProtKB/TrEMBL
      D3Z6T6
      Related
      ENSMUSP00000116183.3, ENSMUST00000155348.3
      Conserved Domains (1) summary
      cd05559
      Location:35 → 168
      CAP_PI16_HrTT-1; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of peptidase inhibitor 16 and HrTT-1 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ET66.2 GenPept UniProtKB/Swiss-Prot:Q9ET66

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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