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    Dancr differentiation antagonizing non-protein coding RNA [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912083, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dancrprovided by RGD
    Official Full Name
    differentiation antagonizing non-protein coding RNAprovided by RGD
    Primary source
    RGD:6489076
    See related
    AllianceGenome:RGD:6489076
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within response to wounding. Orthologous to human DANCR (differentiation antagonizing non-protein coding RNA). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 26.3), Thymus (RPKM 19.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dancr in Genome Data Viewer
    Location:
    14p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (34481052..34482032, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (34126956..34127936, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (36664036..36665016, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481840 Neighboring gene uncharacterized LOC102554412 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene ubiquitin specific peptidase 46 Neighboring gene WW domain binding protein 11, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CRISPR activation of long non-coding RNA DANCR promotes bone regeneration. Nguyen NTK, et al. Biomaterials, 2021 Aug. PMID 34147719
    2. Long non-coding RNA DANCR alleviates hypoxia-caused H9c2 cells damage through up regulation of HIF-1α. Qiu L, et al. Artif Cells Nanomed Biotechnol, 2020 Dec. PMID 32041436
    3. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324. Li J, et al. Mol Med Rep, 2021 Feb. PMID 33300079, Free PMC Article
    4. LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway. Wu M, et al. Eur J Pharmacol, 2023 Jul 5. PMID 37116560
    5. MicroRNA-33a-5p sponges to inhibit pancreatic β-cell function in gestational diabetes mellitus LncRNA DANCR. Feng Y, et al. Reprod Biol Endocrinol, 2020 Jun 6. PMID 32505219, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
      Title: LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
    2. CRISPR activation of long non-coding RNA DANCR promotes bone regeneration.
      Title: CRISPR activation of long non-coding RNA DANCR promotes bone regeneration.
    3. Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324.
      Title: Overexpression of lncRNA Dancr inhibits apoptosis and enhances autophagy to protect cardiomyocytes from endoplasmic reticulum stress injury via sponging microRNA-6324.
    4. MicroRNA-33a-5p sponges to inhibit pancreatic beta-cell function in gestational diabetes mellitus LncRNA DANCR.
      Title: MicroRNA-33a-5p sponges to inhibit pancreatic β-cell function in gestational diabetes mellitus LncRNA DANCR.
    5. Long non-coding RNA DANCR alleviates hypoxia-caused H9c2 cells damage through up regulation of HIF-1alpha.
      Title: Long non-coding RNA DANCR alleviates hypoxia-caused H9c2 cells damage through up regulation of HIF-1α.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_130115.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      34481052..34482032 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.