Skil SKI-like proto-oncogene [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Skilprovided by RGD
Official Full Name: SKI-like proto-oncogeneprovided by RGD
Primary source: RGD:621399
See related: EnsemblRapid:ENSRNOG00000009899 AllianceGenome:RGD:621399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sno; Skir
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and identical protein binding activity. Involved in positive regulation of axonogenesis; response to cytokine; and spermatogenesis. Located in acrosomal vesicle and nucleus. Biomarker of ureteral obstruction. Orthologous to human SKIL (SKI like proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 108.3), Lung (RPKM 95.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (114175534..114203663, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (112247047..112275176, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (115862932..115891304, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SKIL/SnoN attenuates TGF-beta1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis.
Title: SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis.
Ski-related novel protein suppresses the development of diabetic nephropathy by modulating kidney transforming growth factor-beta signaling and microRNA-21 expression.
Title: Ski-related novel protein suppresses the development of diabetic nephropathy by modulating transforming growth factor-β signaling and microRNA-21 expression.
TAK1 mediated the phosphorylation of Ski-related novel protein N (SnoN), resulting in SnoN ubiquitination and eventual degradation, which enhanced EMT and extracellular matrix deposition to promote renal fibrosis during diabetic nephropathy.
Title: TAK1 may promote the development of diabetic nephropathy by reducing the stability of SnoN protein.
BMP7 may ameliorate diabetic nephropathy and renal fibrosis via increasing the expression of SnoN mRNA and protein in renal tubular epithelial cells, rather than directly inhibiting the degradation of SnoN by E3 ubiquitin ligase.
Title: BMP-7 enhances SnoN mRNA expression in renal tubular epithelial cells under high-glucose conditions.
Studied the effects of herbal compound 861 on transforming growth factor beta1 (TGF-beta1)/Sma and Mad-related proteins (Smad)/Ski-related novel protein N (SnoN) signal pathway in a rat hepatic fibrosis disease model.
Title: Herbal compound 861 prevents hepatic fibrosis by inhibiting the TGF-β1/Smad/SnoN pathway in bile duct-ligated rats.
The effect of smurf2 on the degradation of SnoN by ubiquitination was found to be a key factor in diabetic nephropathy, which was mediated by the TGFbeta1/Smad signaling pathway.
Title: Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.
High glucose stress suppresses SnoN while activating TGF-beta1 and Rnf111 (Arkadia) in renal tubular epithelial cells and diabetic rats.
Title: SnoN upregulation ameliorates renal fibrosis in diabetic nephropathy.
SnoN plays a negative role in proximal kidney tubule cells from patients with high glucose-induced epithelial-mesenchymal transition.
Title: SnoN as a key regulator of the high glucose-induced epithelial-mesenchymal transition in cells of the proximal tubule.
findings define a novel SnoN-Ccd1 link that promotes axonal growth in the mammalian brain, with important implications for axonal development and regeneration
Title: A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.
c-Ski has an essential role in mediating TGF-beta1-induced bi-directional effects on skin fibroblast proliferation through a feedback loop
Title: The essential role for c-Ski in mediating TGF-beta1-induced bi-directional effects on skin fibroblast proliferation through a feedback loop.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Skil (e-PCR), detects polymorphism
- UniSTS:463225

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens fiber cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphocyte homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth factor	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ski-like protein

Names: SKI-like oncogene; ski/sno related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398590.1 → NP_001385519.1 ski-like protein isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

D3ZWL1

Related

ENSRNOP00000013191.2, ENSRNOT00000013191.7

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:518 → 668

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
NM_001398591.1 → NP_001385520.1 ski-like protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

Related

ENSRNOP00000086486.1, ENSRNOT00000114271.2

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:472 → 622

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

114175534..114203663 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281143.1 → XP_063137213.1 ski-like protein isoform X4
XM_039103606.1 → XP_038959534.1 ski-like protein isoform X1

UniProtKB/TrEMBL

A0A8I6A1B8, D3ZWL1

Conserved Domains (3) summary

smart01046
Location:258 → 353

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

TIGR02168
Location:518 → 668

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21084
Location:134 → 233

DHD_Sno; Dachshund-homology domain found in Ski-like protein (Sno) and similar proteins
XM_063281142.1 → XP_063137212.1 ski-like protein isoform X3

UniProtKB/TrEMBL

A6IHK2
XM_063281141.1 → XP_063137211.1 ski-like protein isoform X2

UniProtKB/TrEMBL

A6IHK3