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    Rps4x ribosomal protein S4, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 20102, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rps4xprovided by MGI
    Official Full Name
    ribosomal protein S4, X-linkedprovided by MGI
    Primary source
    MGI:MGI:98158
    See related
    Ensembl:ENSMUSG00000031320 AllianceGenome:MGI:98158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rps4; Rps4-1
    Summary
    A structural constituent of ribosome. Predicted to be involved in ribosomal small subunit biogenesis and translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to several human genes including RPS4X (ribosomal protein S4 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 580.8), liver E14 (RPKM 549.2) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps4x in Genome Data Viewer
    Location:
    X D; X 45.2 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101228548..101232929, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102184941..102189391, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene excision repair cross-complementing rodent repair deficiency complementation group 6 like Neighboring gene STARR-positive B cell enhancer ABC_E2538 Neighboring gene protein phosphatase 1 regulatory subunit 14B pseudogene Neighboring gene predicted gene 14859 Neighboring gene Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of the Rps4 gene on the mouse X chromosome. Zinn AR, et al. Genomics, 1991 Dec. PMID 1783379
    2. Expression level of Rps4 mRNA in 39,X mice and 40,XX mice. Omoe K, et al. Cytogenet Cell Genet, 1994. PMID 8187552
    3. Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system. Bressler SL, et al. Somat Cell Mol Genet, 1993 Jan. PMID 7681608
    4. Use of a reverse transcriptase-polymerase chain reaction assay to analyze allele-specific expression in individual hippocampal neurons. Shen SI, et al. Mol Genet Metab, 1998 Feb. PMID 9562962
    5. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome. Fisher EM, et al. Cell, 1990 Dec 21. PMID 2124517

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102174, MGC118104

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of small ribosomal subunit ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein eS4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425993.1 → NP_001412922.1  small ribosomal subunit protein eS4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL954850

    2. NM_001425994.1 → NP_001412923.1  small ribosomal subunit protein eS4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL954850

    3. NM_001425995.1 → NP_001412924.1  small ribosomal subunit protein eS4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954850
      UniProtKB/TrEMBL
      Q545F8

    4. NM_009094.3 → NP_033120.1  small ribosomal subunit protein eS4 isoform 2

      See identical proteins and their annotated locations for NP_033120.1

      Status: VALIDATED

      Source sequence(s)
      AL954850
      Consensus CDS
      CCDS41083.1
      UniProtKB/Swiss-Prot
      P62702, Q9CXN0
      UniProtKB/TrEMBL
      Q3UXQ6, Q545X8
      Related
      ENSMUSP00000033683.8, ENSMUST00000033683.8
      Conserved Domains (1) summary
      PLN00036
      Location:1 → 260
      PLN00036; 40S ribosomal protein S4; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      101228548..101232929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62702.2 GenPept UniProtKB/Swiss-Prot:P62702

    Gene LinkOut

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