MAP2K7 mitogen-activated protein kinase kinase 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAP2K7provided by HGNC
Official Full Name: mitogen-activated protein kinase kinase 7provided by HGNC
Primary source: HGNC:HGNC:6847
See related: Ensembl:ENSG00000076984 MIM:603014; AllianceGenome:HGNC:6847
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4
Summary: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression: Ubiquitous expression in testis (RPKM 9.3), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (7903877..7914478)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (7904832..7915433)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (7968762..7979363)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
Title: Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in Anaplastic Thyroid Cancer.
Combined PDE4+MEK inhibition shows antiproliferative effects in NRASQ61 mutated melanoma preclinical models.
Title: Combined PDE4+MEK inhibition shows antiproliferative effects in NRASQ61 mutated melanoma preclinical models.
IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.
Title: IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts.
Transcription factor ZNF488 accelerates cervical cancer progression through regulating the MEK/ERK signaling pathway.
Title: Transcription factor ZNF488 accelerates cervical cancer progression through regulating the MEK/ERK signaling pathway.
FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy.
Title: FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy.
Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.
Title: Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition.
Low expression of PGC-1beta and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.
Title: Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.
Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.
Title: Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.
A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAF(V600E/K) -mutant Solid Tumors.
Title: A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAF(V600E/K) -mutant Solid Tumors.
A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.
Title: A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Activation of TAK1 by HIV-1 Vpr leads to increased levels of phosphorylated IKK-beta and MKK7 in cells	PubMed
	vpr	Synthetic HIV-1 Vpr protein activates AP-1 (Jun/Fos), c-Jun N-terminal kinase (JNK), NF-kappaB, and MKK7 in both U937 cells and primary macrophages.	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-105254 (e-PCR)
- UniSTS:169256

G43572 (e-PCR)
- UniSTS:95019

D8S2279 (e-PCR)
- UniSTS:473907

RH65754 (e-PCR)
- UniSTS:33867

D15S1477 (e-PCR)
- UniSTS:474482

D1S1425 (e-PCR)
- UniSTS:149621

WI-17148 (e-PCR)
- UniSTS:58520

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables JUN kinase kinase activity	TAS Traceable Author Statement more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular function activator activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Fc-epsilon receptor signaling pathway	TAS Traceable Author Statement more info
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	TAS Traceable Author Statement more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	TAS Traceable Author Statement more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of motor neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in response to heat	IDA Inferred from Direct Assay more info	PubMed
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 7

Names: JNK-activating kinase 2; MAP kinase kinase 7; MAPK/ERK kinase 7; SAPK kinase 4; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4

NP_001284484.1

EC 2.7.12.2

NP_001284485.1

EC 2.7.12.2

NP_660186.1

EC 2.7.12.2

XP_006722863.1

EC 2.7.12.2

XP_054177441.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029438.2 RefSeqGene

Range

4998..15599

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297555.2 → NP_001284484.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 1

See identical proteins and their annotated locations for NP_001284484.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK098807, AK300988, BC038295, BF445461, DQ445915, HY063492

Consensus CDS

CCDS74277.1

UniProtKB/TrEMBL

B4DV95

Related

ENSP00000381070.2, ENST00000397983.7

Conserved Domains (1) summary

cd06618
Location:120 → 416

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_001297556.2 → NP_001284485.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 2

See identical proteins and their annotated locations for NP_001284485.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AK098807, AK300988, BC038295, BF445461, HY063492

Consensus CDS

CCDS74278.1

UniProtKB/TrEMBL

B4DV95

Related

ENSP00000381068.3, ENST00000397981.7

Conserved Domains (1) summary

cd06618
Location:104 → 407

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7
NM_145185.4 → NP_660186.1 dual specificity mitogen-activated protein kinase kinase 7 isoform 3

See identical proteins and their annotated locations for NP_660186.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AF022805, AK098807, BC038295, BF445461, HY063492

Consensus CDS

CCDS42491.1

UniProtKB/Swiss-Prot

B2R9S5, D6W659, O14648, O14733, O14816, O60452, O60453, Q1PG43, Q8IY10

UniProtKB/TrEMBL

B4DV95

Related

ENSP00000381066.3, ENST00000397979.4

Conserved Domains (1) summary

cd06618
Location:104 → 400

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

7903877..7914478

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006722800.3 → XP_006722863.1 dual specificity mitogen-activated protein kinase kinase 7 isoform X1

See identical proteins and their annotated locations for XP_006722863.1

UniProtKB/TrEMBL

B4DV95

Conserved Domains (1) summary

cd06618
Location:120 → 423

PKc_MKK7; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7