Trp73 transformation related protein 73 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trp73provided by MGI
Official Full Name: transformation related protein 73provided by MGI
Primary source: MGI:MGI:1336991
See related: Ensembl:ENSMUSG00000029026 AllianceGenome:MGI:1336991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p73; Tp73; TAp73; deltaNp73
Summary: This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lung adult (RPKM 1.7), ovary adult (RPKM 1.4) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.79 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (154140706..154224332, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154056249..154139875, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Title: Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.
Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model.
Title: Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model.
Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73gamma in tumorigenesis via leptin.
Title: Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin.
Pulsed Electromagnetic Fields Combined With Adipose-Derived Stem Cells Protect Ischemic Myocardium by Regulating miR-20a-5p/E2F1/p73 Signaling.
Title: Pulsed Electromagnetic Fields Combined With Adipose-Derived Stem Cells Protect Ischemic Myocardium by Regulating miR-20a-5p/E2F1/p73 Signaling.
TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response.
Title: TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response.
p73alpha1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.
Title: p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1.
P73 C-terminus is dispensable for multiciliogenesis.
Title: P73 C-terminus is dispensable for multiciliogenesis.
Molecular Mechanisms and Function of the p53 Protein Family Member - p73.
Title: Molecular Mechanisms and Function of the p53 Protein Family Member - p73.
p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?
Title: p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?
Cajal-Retzius neurons are required for the development of the human hippocampal fissure.
Title: Cajal-Retzius neurons are required for the development of the human hippocampal fissure.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trp73 (e-PCR), detects polymorphism
- UniSTS:144678

Trp73 (e-PCR), detects polymorphism
- UniSTS:144679

Trp73 (e-PCR), detects polymorphism
- UniSTS:144680

Trp73 (e-PCR), detects polymorphism
- UniSTS:144681

D4Mit344 (e-PCR), detects polymorphism
- UniSTS:130137

NoName (e-PCR)
- UniSTS:235114

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebrospinal fluid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lung ciliated cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect regulation of cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tumor protein p73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126330.1 → NP_001119802.1 tumor protein p73 isoform b

See identical proteins and their annotated locations for NP_001119802.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is an alternate promoter product; it lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform b, also known as DNp73alpha, has a shorter and different N-terminus, as compared to isoform a.

Source sequence(s)

AK014503, AK139633, Y19235

Consensus CDS

CCDS51397.1

UniProtKB/TrEMBL

Z4YK94

Related

ENSMUSP00000114418.2, ENSMUST00000133533.8

Conserved Domains (5) summary

cd09571
Location:440 → 504

SAM_tumor-p73; SAM domain of tumor-p73 proteins

smart00454
Location:444 → 504

SAM; Sterile alpha motif

pfam00870
Location:64 → 260

P53; P53 DNA-binding domain

pfam07710
Location:296 → 335

P53_tetramer; P53 tetramerization motif

pfam09646
Location:499 → 589

Gp37; Gp37 protein
NM_001126331.1 → NP_001119803.1 tumor protein p73 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) is an alternate promoter product; it lacks a few of 5' exons and two internal exons in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform c, also known as DNp73zeta, has a shorter and different N-terminus and lacks an internal segment in the C-terminal region, as compared to isoform a.

Source sequence(s)

AK014503, AK017412, AK139633

Consensus CDS

CCDS51396.1

UniProtKB/Swiss-Prot

Q9JJP2

UniProtKB/TrEMBL

Q9D6A3

Related

ENSMUSP00000095368.5, ENSMUST00000097762.11

Conserved Domains (5) summary

smart00454
Location:353 → 408

SAM; Sterile alpha motif

pfam00870
Location:64 → 260

P53; P53 DNA-binding domain

pfam07710
Location:296 → 335

P53_tetramer; P53 tetramerization motif

pfam09646
Location:403 → 493

Gp37; Gp37 protein

cl15755
Location:353 → 408

SAM_superfamily; SAM (Sterile alpha motif )
NM_011642.4 → NP_035772.3 tumor protein p73 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform a, also known as TAp73alpha.

Source sequence(s)

AL806525

Consensus CDS

CCDS19009.2

UniProtKB/Swiss-Prot

B1AX89, B1AX90, Q3UT91, Q9CU77, Q9JJP1, Q9JJP2, Q9WUJ0

UniProtKB/TrEMBL

Z4YK94

Related

ENSMUSP00000101269.4, ENSMUST00000105644.10

Conserved Domains (4) summary

cd09571
Location:481 → 545

SAM_tumor-p73; SAM domain of tumor-p73 proteins

pfam00870
Location:105 → 301

P53; P53 DNA-binding domain

pfam07710
Location:338 → 376

P53_tetramer; P53 tetramerisation motif

pfam09646
Location:540 → 630

Gp37; Gp37 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

154140706..154224332 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538720.2 → XP_006538783.2 tumor protein p73 isoform X1

UniProtKB/TrEMBL

Z4YK94

Conserved Domains (4) summary

cd08367
Location:137 → 316

P53; P53 DNA-binding domain

cd09571
Location:499 → 563

SAM_tumor-p73; SAM domain of tumor-p73 proteins

pfam07710
Location:356 → 392

P53_tetramer; P53 tetramerisation motif

pfam09646
Location:558 → 648

Gp37; Gp37 protein
XM_006538722.5 → XP_006538785.1 tumor protein p73 isoform X2

See identical proteins and their annotated locations for XP_006538785.1

UniProtKB/TrEMBL

Z4YK94

Conserved Domains (4) summary

cd08367
Location:56 → 235

P53; P53 DNA-binding domain

cd09571
Location:418 → 482

SAM_tumor-p73; SAM domain of tumor-p73 proteins

pfam07710
Location:275 → 311

P53_tetramer; P53 tetramerisation motif

pfam09646
Location:477 → 567

Gp37; Gp37 protein
XM_006538723.3 → XP_006538786.1 tumor protein p73 isoform X3

Conserved Domains (4) summary

cd08367
Location:4 → 101

P53; P53 DNA-binding domain

cd09571
Location:284 → 348

SAM_tumor-p73; SAM domain of tumor-p73 proteins

pfam07710
Location:141 → 177

P53_tetramer; P53 tetramerisation motif

pfam09646
Location:343 → 433

Gp37; Gp37 protein