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    GAPVD1 GTPase activating protein and VPS9 domains 1 [ Homo sapiens (human) ]

    Gene ID: 26130, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GAPVD1provided by HGNC
    Official Full Name
    GTPase activating protein and VPS9 domains 1provided by HGNC
    Primary source
    HGNC:HGNC:23375
    See related
    Ensembl:ENSG00000165219 MIM:611714; AllianceGenome:HGNC:23375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RAP6; GAPEX5; GAPex-5
    Summary
    Enables GTPase activating protein binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of protein transport. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 13.1), thyroid (RPKM 9.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GAPVD1 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (125261826..125367207)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137460127..137566391)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (128024105..128129486)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29000 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:128003252-128003756 and GRCh37_chr9:128003757-128004261 Neighboring gene Sharpr-MPRA regulatory region 12295 Neighboring gene HSPA5 divergent transcript Neighboring gene heat shock protein family A (Hsp70) member 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128020420-128020678 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128024002-128024183 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:128029981-128030481 Neighboring gene ribosomal protein S10 pseudogene 17 Neighboring gene RNA, U6 small nuclear 1020, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr9:128115126-128115299 Neighboring gene Sharpr-MPRA regulatory region 13338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128133357-128133857 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:128152293-128153032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:128169974-128170568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29002 Neighboring gene uncharacterized LOC101929014 Neighboring gene uncharacterized LOC112268055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:128186118-128186618 Neighboring gene RNA, U5B small nuclear 5, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis. Khademi B, et al. J Neuroimmunol, 2021 Apr 15. PMID 33548618
    2. Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis. Hunker CM, et al. Biochem Biophys Res Commun, 2006 Feb 17. PMID 16410077
    3. Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation. Ibrahim H, et al. Int J Mol Sci, 2021 Apr 6. PMID 33917494, Free PMC Article
    4. CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1. Guillen RX, et al. Sci Rep, 2020 Apr 22. PMID 32321936, Free PMC Article
    5. SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis. Kim H, et al. Exp Mol Med, 2019 Jul 29. PMID 31358736, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
      Title: An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
    2. Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
      Title: Phosphorylation of GAPVD1 Is Regulated by the PER Complex and Linked to GAPVD1 Degradation.
    3. CRISPR-mediated gene targeting of CK1delta/epsilon leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.
      Title: CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.
    4. The findings suggest that SPIN90, as an adaptor protein, simultaneously binds inactive Rab5 and Gapex5, thereby altering their spatial proximity and facilitating Rab5 activation.
      Title: SPIN90, an adaptor protein, alters the proximity between Rab5 and Gapex5 and facilitates Rab5 activation during EGF endocytosis.
    5. EGF-stimulated receptor ubiquitination and trafficking are mediated via GAPex-5: GAPex-5-mediated EGFR ubiquitination is independent of Rab5 activation
      Title: GAPex-5 mediates ubiquitination, trafficking, and degradation of epidermal growth factor receptor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of GAPVD1 PubMed
    Knockdown of GTPase activating protein and VPS9 domains 1 (GAPVD1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1521, MGC138847, MGC138848, DKFZp434C212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activating protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein and VPS9 domain-containing protein 1
    Names
    Rab5 exchange factor
    Rab5-activating protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282679.2 → NP_001269608.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001269608.1

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65132.1
      UniProtKB/Swiss-Prot
      A8MYK3, B0QZ62, B0QZ63, B0QZ64, Q14C76, Q14C86, Q2Q1W1, Q8ND92, Q8WU86, Q96CZ4, Q9NXQ1, Q9P207, Q9Y4N0
      Related
      ENSP00000419063.1, ENST00000495955.5
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1374 → 1475
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1263 → 1326
      DUF5601; Domain of unknown function (DUF5601)

    2. NM_001282680.3 → NP_001269609.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001269609.1

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Related
      ENSP00000297933.6, ENST00000297933.11
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    3. NM_001282681.3 → NP_001269610.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001269610.1

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65130.1
      UniProtKB/Swiss-Prot
      Q14C86
      Related
      ENSP00000309582.9, ENST00000312123.13
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1335 → 1436
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1224 → 1287
      DUF5601; Domain of unknown function (DUF5601)

    4. NM_001330777.3 → NP_001317706.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS83413.1
      UniProtKB/TrEMBL
      F8W9S7
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1308 → 1409
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1197 → 1260
      DUF5601; Domain of unknown function (DUF5601)

    5. NM_001330778.3 → NP_001317707.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS83414.1
      Related
      ENSP00000419767.1, ENST00000470056.5
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1329 → 1430
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1218 → 1281
      DUF5601; Domain of unknown function (DUF5601)

    6. NM_001354293.2 → NP_001341222.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AA683411, AL354710, BC110990
      Consensus CDS
      CCDS87689.1
      UniProtKB/TrEMBL
      B0QZ65
      Related
      ENSP00000377646.1, ENST00000394084.5
      Conserved Domains (1) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6

    7. NM_001354294.2 → NP_001341223.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    8. NM_001354295.2 → NP_001341224.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    9. NM_001354296.2 → NP_001341225.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    10. NM_001354297.2 → NP_001341226.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65130.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1335 → 1436
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1224 → 1287
      DUF5601; Domain of unknown function (DUF5601)

    11. NM_001354298.2 → NP_001341227.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    12. NM_001354299.2 → NP_001341228.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    13. NM_001354300.2 → NP_001341229.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65130.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1335 → 1436
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1224 → 1287
      DUF5601; Domain of unknown function (DUF5601)

    14. NM_001354301.2 → NP_001341230.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS65131.1
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    15. NM_015635.4 → NP_056450.2  GTPase-activating protein and VPS9 domain-containing protein 1 isoform 4

      See identical proteins and their annotated locations for NP_056450.2

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223
      Consensus CDS
      CCDS35138.1
      Related
      ENSP00000377665.2, ENST00000394105.6
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1383 → 1484
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1272 → 1335
      DUF5601; Domain of unknown function (DUF5601)

    RNA

    1. NR_148732.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223

    2. NR_148733.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL354710, AL627223

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      125261826..125367207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423183.1 → XP_047279139.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    2. XM_047423204.1 → XP_047279160.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    3. XM_047423182.1 → XP_047279138.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    4. XM_047423193.1 → XP_047279149.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    5. XM_047423205.1 → XP_047279161.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    6. XM_047423200.1 → XP_047279156.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    7. XM_047423180.1 → XP_047279136.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    8. XM_047423189.1 → XP_047279145.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    9. XM_047423194.1 → XP_047279150.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    10. XM_047423207.1 → XP_047279163.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7

    11. XM_047423181.1 → XP_047279137.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    12. XM_047423202.1 → XP_047279158.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    13. XM_047423186.1 → XP_047279142.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    14. XM_047423195.1 → XP_047279151.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    15. XM_047423208.1 → XP_047279164.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7

    16. XM_047423179.1 → XP_047279135.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    17. XM_047423190.1 → XP_047279146.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    18. XM_047423196.1 → XP_047279152.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    19. XM_047423177.1 → XP_047279133.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    20. XM_047423201.1 → XP_047279157.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    21. XM_047423187.1 → XP_047279143.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    22. XM_011518500.3 → XP_011516802.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011516802.1

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1383 → 1484
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1272 → 1335
      DUF5601; Domain of unknown function (DUF5601)

    23. XM_047423192.1 → XP_047279148.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

    24. XM_017014609.2 → XP_016870098.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1329 → 1430
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1218 → 1281
      DUF5601; Domain of unknown function (DUF5601)

    25. XM_047423185.1 → XP_047279141.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    26. XM_047423198.1 → XP_047279154.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

    27. XM_017014606.2 → XP_016870095.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

      UniProtKB/Swiss-Prot
      Q14C86
      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1335 → 1436
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1224 → 1287
      DUF5601; Domain of unknown function (DUF5601)

    28. XM_011518499.3 → XP_011516801.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011516801.1

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1383 → 1484
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1272 → 1335
      DUF5601; Domain of unknown function (DUF5601)

    29. XM_011518507.3 → XP_011516809.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1356 → 1457
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1245 → 1308
      DUF5601; Domain of unknown function (DUF5601)

    30. XM_005251904.4 → XP_005251961.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

      See identical proteins and their annotated locations for XP_005251961.1

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1329 → 1430
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1218 → 1281
      DUF5601; Domain of unknown function (DUF5601)

    31. XM_011518506.3 → XP_011516808.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

      Conserved Domains (3) summary
      cd05129
      Location:84 → 449
      RasGAP_RAP6; Ras-GTPase Activating Domain of Rab5-activating protein 6
      pfam02204
      Location:1362 → 1463
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      pfam18151
      Location:1251 → 1314
      DUF5601; Domain of unknown function (DUF5601)

    32. XM_047423178.1 → XP_047279134.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    33. XM_047423191.1 → XP_047279147.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    34. XM_047423203.1 → XP_047279159.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    35. XM_047423188.1 → XP_047279144.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    36. XM_047423197.1 → XP_047279153.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    37. XM_047423209.1 → XP_047279165.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7

    38. XM_047423184.1 → XP_047279140.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    39. XM_047423199.1 → XP_047279155.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

    40. XM_047423206.1 → XP_047279162.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7
      Related
      ENSP00000377645.2, ENST00000394083.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137460127..137566391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362667.1 → XP_054218642.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    2. XM_054362666.1 → XP_054218641.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    3. XM_054362678.1 → XP_054218653.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    4. XM_054362693.1 → XP_054218668.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    5. XM_054362686.1 → XP_054218661.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    6. XM_054362664.1 → XP_054218639.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    7. XM_054362673.1 → XP_054218648.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    8. XM_054362680.1 → XP_054218655.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    9. XM_054362695.1 → XP_054218670.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7

    10. XM_054362665.1 → XP_054218640.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    11. XM_054362691.1 → XP_054218666.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    12. XM_054362671.1 → XP_054218646.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    13. XM_054362681.1 → XP_054218656.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    14. XM_054362696.1 → XP_054218671.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7

    15. XM_054362663.1 → XP_054218638.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    16. XM_054362674.1 → XP_054218649.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    17. XM_054362682.1 → XP_054218657.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    18. XM_054362661.1 → XP_054218636.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    19. XM_054362690.1 → XP_054218665.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    20. XM_054362672.1 → XP_054218647.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    21. XM_054362687.1 → XP_054218662.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    22. XM_054362660.1 → XP_054218635.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    23. XM_054362677.1 → XP_054218652.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

    24. XM_054362688.1 → XP_054218663.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    25. XM_054362670.1 → XP_054218645.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    26. XM_054362684.1 → XP_054218659.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

    27. XM_054362679.1 → XP_054218654.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    28. XM_054362659.1 → XP_054218634.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    29. XM_054362676.1 → XP_054218651.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X4

    30. XM_054362689.1 → XP_054218664.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    31. XM_054362668.1 → XP_054218643.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    32. XM_054362662.1 → XP_054218637.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1

    33. XM_054362675.1 → XP_054218650.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X3

    34. XM_054362692.1 → XP_054218667.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X7

    35. XM_054362683.1 → XP_054218658.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X5

    36. XM_054362669.1 → XP_054218644.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X2

    37. XM_054362685.1 → XP_054218660.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X6

    38. XM_054362694.1 → XP_054218669.1  GTPase-activating protein and VPS9 domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      F8W9S7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14C86.2 GenPept UniProtKB/Swiss-Prot:Q14C86

    Gene LinkOut

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