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    Sun5 Sad1 and UNC84 domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296289, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Sun5provided by RGD
    Official Full Name
    Sad1 and UNC84 domain containing 5provided by RGD
    Primary source
    RGD:1306357
    See related
    EnsemblRapid:ENSRNOG00000027221 AllianceGenome:RGD:1306357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spag4l
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in nuclear envelope organization and spermatid development. Predicted to be located in nuclear inner membrane and sperm connecting piece. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in nuclear envelope. Human ortholog(s) of this gene implicated in spermatogenic failure 16. Orthologous to human SUN5 (Sad1 and UNC84 domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 90.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sun5 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (162795096..162815521, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (142334931..142355349, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (149336136..149356191, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein, RP/EB family, member 1 Neighboring gene uncharacterized LOC120101759 Neighboring gene uncharacterized LOC134486189 Neighboring gene EF-hand calcium binding domain 8 Neighboring gene BPI fold containing family B, member 2 Neighboring gene BPI fold containing family B, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic SUN5 Mutations Cause Autosomal-Recessive Acephalic Spermatozoa Syndrome. Zhu F, et al. Am J Hum Genet, 2016 Oct 6. PMID 27640305, Free PMC Article
    2. [Cloning of cDNA of TSARG4, a human spermatogenesis related gene]. Xing XW, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 2003 Mar. PMID 12621555
    3. Essential role for SUN5 in anchoring sperm head to the tail. Shang Y, et al. Elife, 2017 Sep 25. PMID 28945193, Free PMC Article
    4. Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene. Shang Y, et al. J Biol Chem, 2018 Feb 16. PMID 29298896, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of meiotic nuclear membrane microtubule tethering complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SUN domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415685.1 → NP_001402614.1  SUN domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2KBB4
      Related
      ENSRNOP00000075726.1, ENSRNOT00000081775.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      162795096..162815521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106530.1: Suppressed sequence

      Description
      NM_001106530.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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