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    Qsox2 quiescin sulfhydryl oxidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681023, updated on 17-Aug-2024

    Summary

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    Symbol
    Qsox2provided by RGD
    Full Name
    quiescin sulfhydryl oxidase 2provided by RGD
    Primary source
    RGD:1584720
    See related
    EnsemblRapid:ENSRNOG00000018574 AllianceGenome:RGD:1584720
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable flavin-linked sulfhydryl oxidase activity and protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in extracellular space. Predicted to be integral component of Golgi membrane. Orthologous to human QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 77.9), Adrenal (RPKM 56.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (29433091..29462739, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (9034994..9064649, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (3662324..3691972, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 250 Neighboring gene LIM homeobox 3 Neighboring gene uncharacterized LOC120101510 Neighboring gene coiled-coil domain containing 187 Neighboring gene G-protein signaling modulator 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfhydryl oxidase 2
    Names
    quiescin Q6 sulfhydryl oxidase 2
    NP_001102904.1
    XP_017447529.1
    XP_038961783.1
    XP_063140615.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109434.1 → NP_001102904.1  sulfhydryl oxidase 2

      See identical proteins and their annotated locations for NP_001102904.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      A6JTC7, D3ZP13
      Related
      ENSRNOP00000058448.3, ENSRNOT00000061735.4
      Conserved Domains (2) summary
      cd02992
      Location:71 → 184
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:441 → 538
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      29433091..29462739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592040.3 → XP_017447529.1  sulfhydryl oxidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ARL2
      Related
      ENSRNOP00000096929.1, ENSRNOT00000116146.2

    2. XM_039105855.2 → XP_038961783.1  sulfhydryl oxidase 2 isoform X2

      Conserved Domains (3) summary
      pfam04777
      Location:260 → 345
      Evr1_Alr; Erv1 / Alr family
      pfam18108
      Location:14 → 121
      QSOX_Trx1; QSOX Trx-like domain
      pfam18371
      Location:147 → 250
      FAD_SOX; Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase

    3. XM_063284545.1 → XP_063140615.1  sulfhydryl oxidase 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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