Dppa3 developmental pluripotency-associated 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dppa3provided by RGD
Official Full Name: developmental pluripotency-associated 3provided by RGD
Primary source: RGD:1310932
See related: EnsemblRapid:ENSRNOG00000022950 AllianceGenome:RGD:1310932
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in negative regulation of DNA demethylation; protection of DNA demethylation of female pronucleus; and regulation of genetic imprinting. Predicted to act upstream of or within embryonic cleavage. Predicted to be located in cytoplasm; female pronucleus; and male pronucleus. Predicted to be active in nucleus. Orthologous to human DPPA3 (developmental pluripotency associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 31.7), Spleen (RPKM 25.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (157523426..157526810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (155851461..155854845)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (155437675..155441059)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Dppa3 (e-PCR), detects polymorphism
- UniSTS:254292

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryonic cleavage	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programing of female pronucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in epigenetic programing of female pronucleus	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programing of female pronucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in female pronucleus	ISO Inferred from Sequence Orthology more info
located_in female pronucleus	ISS Inferred from Sequence or Structural Similarity more info
NOT located_in male pronucleus	ISO Inferred from Sequence Orthology more info
located_in male pronucleus	ISO Inferred from Sequence Orthology more info
NOT located_in male pronucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: developmental pluripotency-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.