Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srgap2provided by RGD
Official Full Name: SLIT-ROBO Rho GTPase activating protein 2provided by RGD
Primary source: RGD:1566016
See related: EnsemblRapid:ENSRNOG00000006733 AllianceGenome:RGD:1566016
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566016
Summary: Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including plasma membrane bounded cell projection organization; substrate adhesion-dependent cell spreading; and synapse assembly. Located in cytoplasm and nucleus. Orthologous to several human genes including SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Lung (RPKM 73.9), Brain (RPKM 70.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45298192..45519330, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42745956..42967091, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (48065280..48286888, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data provide new insights into the specific regulation of the |-Srgap2-Fam72a-| master gene.
Title: A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm.
The translocation of srGAP2 in the cytoplasm and cell nucleus in different cell types may function as a director in decisions regarding cell fate.
Title: Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro.
results suggest that srGAPs are not only involved in the regulation of the Slit-Robo signal transduction, but also in neuronal development and that the translocation of srGAPs is important for their functions.
Title: Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE108135 (e-PCR)
- UniSTS:247664

AU046573 (e-PCR)
- UniSTS:111324

BE109592 (e-PCR)
- UniSTS:248291

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in actin filament severing	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine development	ISS Inferred from Sequence or Structural Similarity more info
involved_in excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	ISO Inferred from Sequence Orthology more info
involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: SLIT-ROBO Rho GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134958.1 → NP_001128430.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform 2

See identical proteins and their annotated locations for NP_001128430.1

Status: PROVISIONAL

Source sequence(s)

BC168690

UniProtKB/TrEMBL

A0A8I5ZL53, B5DEJ1

Related

ENSRNOP00000008976.5, ENSRNOT00000008976.7

Conserved Domains (3) summary

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

cl12013
Location:26 → 289

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001401376.1 → NP_001388305.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

D4A208

Related

ENSRNOP00000068925.1, ENSRNOT00000085967.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45298192..45519330 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090884.2 → XP_038946812.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZL53

Conserved Domains (4) summary

cd07682
Location:26 → 288

F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2

PHA03269
Location:962 → 1064

PHA03269; envelope glycoprotein C; Provisional

cd11955
Location:731 → 783

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:486 → 673

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
XM_006249783.5 → XP_006249845.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

See identical proteins and their annotated locations for XP_006249845.1

UniProtKB/Swiss-Prot

D4A208

UniProtKB/TrEMBL

A0A8I5ZL53

Conserved Domains (3) summary

cd07682
Location:26 → 289

F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...
XM_006249785.4 → XP_006249847.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I5ZL53

Related

ENSRNOP00000070956.2, ENSRNOT00000086928.3

Conserved Domains (3) summary

cd11955
Location:666 → 718

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:421 → 608

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

cl12013
Location:21 → 223

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039090887.1 → XP_038946815.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X6

UniProtKB/TrEMBL

A0A8I5ZL53

Conserved Domains (4) summary

PHA03269
Location:810 → 912

PHA03269; envelope glycoprotein C; Provisional

cd11955
Location:579 → 631

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:334 → 521

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

cl12013
Location:1 → 136

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039090885.2 → XP_038946813.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X4

UniProtKB/TrEMBL

A0A0G2JZ92, A0A8I5ZL53

Related

ENSRNOP00000112019.1, ENSRNOT00000127076.1

Conserved Domains (3) summary

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

cl12013
Location:26 → 289

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039090886.2 → XP_038946814.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X5

UniProtKB/TrEMBL

A0A8I5ZL53

Conserved Domains (3) summary

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

cl12013
Location:26 → 289

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039090888.2 → XP_038946816.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X7

UniProtKB/TrEMBL

A0A8I5ZL53

Conserved Domains (3) summary

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

cl12013
Location:26 → 289

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature