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    Macir macrophage immunometabolism regulator [ Mus musculus (house mouse) ]

    Gene ID: 52392, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Macirprovided by MGI
    Official Full Name
    macrophage immunometabolism regulatorprovided by MGI
    Primary source
    MGI:MGI:1277184
    See related
    Ensembl:ENSMUSG00000044768 AllianceGenome:MGI:1277184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D1Ertd622e
    Summary
    Acts upstream of or within negative regulation of cytokine production involved in inflammatory response; negative regulation of epithelial cell migration; and negative regulation of fibroblast migration. Predicted to be located in ciliary transition zone and cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 10.5), liver E14.5 (RPKM 10.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Macir in Genome Data Viewer
    Location:
    1 D; 1 47.76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (97571627..97589743, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (97643902..97662018, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01774 Neighboring gene predicted gene 7133 Neighboring gene STARR-seq mESC enhancer starr_01775 Neighboring gene STARR-seq mESC enhancer starr_01776 Neighboring gene STARR-seq mESC enhancer starr_01777 Neighboring gene predicted gene 7135 Neighboring gene STARR-seq mESC enhancer starr_01778 Neighboring gene VISTA enhancer mm1317 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99476944-99477212 Neighboring gene STARR-positive B cell enhancer ABC_E3293 Neighboring gene STARR-seq mESC enhancer starr_01779 Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:99666627-99666810 Neighboring gene STARR-seq mESC enhancer starr_01781 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene predicted gene, 31771

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Muthana M, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26316022, Free PMC Article
    2. Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Yoshida S, et al. Hum Mol Genet, 2004 Jul 15. PMID 15163632
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of fibroblast migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary transition zone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    macrophage immunometabolism regulator
    Names
    UNC119-binding protein C5orf30 homolog
    UPF0684 protein C5orf30 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355071.1 → NP_001342000.1  macrophage immunometabolism regulator

      Status: VALIDATED

      Source sequence(s)
      AC099860
      Consensus CDS
      CCDS15202.1
      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Related
      ENSMUSP00000121997.3, ENSMUST00000149927.2
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    2. NM_001355072.1 → NP_001342001.1  macrophage immunometabolism regulator

      Status: VALIDATED

      Source sequence(s)
      AC099860
      Consensus CDS
      CCDS15202.1
      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Related
      ENSMUSP00000138031.2, ENSMUST00000153115.8
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    3. NM_001355073.1 → NP_001342002.1  macrophage immunometabolism regulator

      Status: VALIDATED

      Source sequence(s)
      AC099860
      Consensus CDS
      CCDS15202.1
      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    4. NM_001355074.1 → NP_001342003.1  macrophage immunometabolism regulator

      Status: VALIDATED

      Source sequence(s)
      AC099860
      Consensus CDS
      CCDS15202.1
      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    5. NM_133825.3 → NP_598586.1  macrophage immunometabolism regulator

      See identical proteins and their annotated locations for NP_598586.1

      Status: VALIDATED

      Source sequence(s)
      AK152370, AK162223, BB611324, BY419889
      Consensus CDS
      CCDS15202.1
      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Related
      ENSMUSP00000051034.8, ENSMUST00000053033.14
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      97571627..97589743 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529751.2 → XP_006529814.1  macrophage immunometabolism regulator isoform X1

      See identical proteins and their annotated locations for XP_006529814.1

      UniProtKB/Swiss-Prot
      Q3UXG2, Q8VEB3
      Conserved Domains (1) summary
      pfam15435
      Location:3 → 201
      UNC119_bdg; UNC119-binding protein C5orf30 homolog
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEB3.1 GenPept UniProtKB/Swiss-Prot:Q8VEB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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