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    crip2 cysteine-rich protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 554826, updated on 28-Oct-2024

    Summary

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    Official Symbol
    crip2provided by ZNC
    Official Full Name
    cysteine-rich protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2889
    See related
    Ensembl:ENSDARG00000070670 AllianceGenome:ZFIN:ZDB-GENE-040426-2889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55408; wu:fb30h10
    Summary
    Predicted to enable metal ion binding activity. Acts upstream of or within heart contraction and heart development. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; neural crest; and notochord. Orthologous to human CRIP2 (cysteine rich protein 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See crip2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (37445525..37474633, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (37497940..37527048, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438049 Neighboring gene uncharacterized LOC137488130 Neighboring gene metastasis associated 1 Neighboring gene transmembrane protein 229B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of LBX2 as a novel causal gene of atrial septal defect. Wang J, et al. Int J Cardiol, 2018 Aug 15. PMID 29669692
    2. Endogenous Natural Complement Inhibitor Regulates Cardiac Development. Mortensen SA, et al. J Immunol, 2017 Apr 15. PMID 28258200
    3. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. Straubinger J, et al. FASEB J, 2017 Apr. PMID 28138039
    4. ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development. Qian M, et al. Dev Biol, 2013 Feb 1. PMID 23201577
    5. Zebrafish Crip2 plays a critical role in atrioventricular valve development by downregulating the expression of ECM genes in the endocardial cushion. Kim JD, et al. Mol Cells, 2014 May. PMID 24823359, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crip2 plays an important role in atrioventricular valve development by downregulating the expression of extracellular matrix components in the endocardial cushion.
      Title: Zebrafish Crip2 plays a critical role in atrioventricular valve development by downregulating the expression of ECM genes in the endocardial cushion.
    2. data suggest a specific role for Wnt3a in the development of cardiac NCCs; propose that this function of wnt3a in r6 is partially mediated by crip2 expression in the premigratory cardiac NCCs, which subsequently affects cardiac function and PA patterning
      Title: Wnt3a regulates the development of cardiac neural crest cells by modulating expression of cysteine-rich intestinal protein 2 in rhombomere 6.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55408, MGC175083

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213497.2 → NP_998662.2  cysteine-rich protein 2

      Status: VALIDATED

      Source sequence(s)
      AL929543
      UniProtKB/TrEMBL
      A0A8M1PFB8, F1QZB0
      Related
      ENSDARP00000094755.3, ENSDART00000103980.4
      Conserved Domains (2) summary
      cd09401
      Location:124 → 177
      LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
      cd09476
      Location:5 → 58
      LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      37445525..37474633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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