U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nono non-POU domain containing, octamer-binding [ Danio rerio (zebrafish) ]

    Gene ID: 321994, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nonoprovided by ZNC
    Official Full Name
    non-POU domain containing, octamer-bindingprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-713
    See related
    Ensembl:ENSDARG00000020482 AllianceGenome:ZFIN:ZDB-GENE-030131-713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb40d10; wu:fc11d05
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within central nervous system development; otic vesicle development; and somite development. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22593624..22603354, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (22089824..22099559, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor (ligand) superfamily, member 10 like 4 Neighboring gene caspase 22, apoptosis-related cysteine peptidase Neighboring gene zgc:113208 Neighboring gene melatonin receptor 1C

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A universal cloning method based on yeast homologous recombination that is simple, efficient, and versatile. Joska TM, et al. J Microbiol Methods, 2014 May. PMID 24418681, Free PMC Article
    2. Evaluation of toxicological endpoints in female zebrafish after bisphenol A exposure. Molina AM, et al. Food Chem Toxicol, 2018 Feb. PMID 29258955
    3. Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Huang L, et al. Sci Rep, 2019 Feb 12. PMID 30755680, Free PMC Article
    4. Large-scale discovery of novel genetic causes of developmental disorders. Deciphering Developmental Disorders Study. Nature, 2015 Mar 12. PMID 25533962, Free PMC Article
    5. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within somite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    non-POU domain-containing octamer-binding protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201579.1 → NP_963873.1  non-POU domain-containing octamer-binding protein

      Status: PROVISIONAL

      Source sequence(s)
      BC046880
      UniProtKB/TrEMBL
      A0A8M2BCB1, Q802Z5
      Related
      ENSDARP00000014106.5, ENSDART00000011699.7
      Conserved Domains (3) summary
      cd12947
      Location:217 → 310
      NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
      cd12591
      Location:147 → 226
      RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:71 → 141
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      22593624..22603354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165105.4 → XP_005165162.1  non-POU domain-containing octamer-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCB1, Q802Z5
      Conserved Domains (3) summary
      cd12947
      Location:217 → 310
      NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
      cd12591
      Location:147 → 226
      RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:71 → 141
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_021476008.1 → XP_021331683.1  non-POU domain-containing octamer-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8M9PX41
      Conserved Domains (3) summary
      cd12947
      Location:217 → 310
      NOPS_p54nrb; NOPS domain, including C-terminal coiled-coil region, in 54 kDa nuclear RNA- and DNA-binding protein (p54nrb) and similar proteins
      cd12591
      Location:147 → 226
      RRM2_p54nrb; RNA recognition motif 2 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:71 → 141
      RRM_SF; RNA recognition motif (RRM) superfamily

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394573.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      109185..122898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools