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    Chrna9 cholinergic receptor, nicotinic, alpha polypeptide 9 [ Mus musculus (house mouse) ]

    Gene ID: 231252, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Chrna9provided by MGI
    Official Full Name
    cholinergic receptor, nicotinic, alpha polypeptide 9provided by MGI
    Primary source
    MGI:MGI:1202403
    See related
    Ensembl:ENSMUSG00000029205 AllianceGenome:MGI:1202403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acra9; Gm8311; EG666827; 2410015I05Rik
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound; inner ear morphogenesis; and monoatomic cation transport. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in cholinergic synapse; neuron projection; and postsynaptic specialization membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in lung small cell carcinoma. Orthologous to human CHRNA9 (cholinergic receptor nicotinic alpha 9 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward thymus adult (RPKM 11.4) See more
    Orthologs
    human all
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    Genomic context

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    See Chrna9 in Genome Data Viewer
    Location:
    5 C3.1; 5 33.84 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66092317..66134823)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65934854..65977486)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66301684-66301897 Neighboring gene STARR-seq mESC enhancer starr_13274 Neighboring gene predicted gene, 32556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66320476-66320836 Neighboring gene STARR-positive B cell enhancer ABC_E1301 Neighboring gene STARR-positive B cell enhancer ABC_E9642 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:66347227-66347446 Neighboring gene STARR-positive B cell enhancer ABC_E6335 Neighboring gene STARR-seq mESC enhancer starr_13277 Neighboring gene RIKEN cDNA 9130230L23 gene Neighboring gene STARR-seq mESC enhancer starr_13278 Neighboring gene predicted gene, 40310

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cell-specific expression of the alpha 9 n-ACh receptor subunit in auditory hair cells revealed by single-cell RT-PCR. Glowatzki E, et al. Proc Biol Sci, 1995 Nov 22. PMID 8524909
    2. The precise temporal pattern of prehearing spontaneous activity is necessary for tonotopic map refinement. Clause A, et al. Neuron, 2014 May 21. PMID 24853941, Free PMC Article
    3. Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice. Callaghan B, et al. Channels (Austin), 2010 Jan-Feb. PMID 20368690
    4. α9-nicotinic acetylcholine receptors contribute to the maintenance of chronic mechanical hyperalgesia, but not thermal or mechanical allodynia. Mohammadi S, et al. Mol Pain, 2014 Oct 2. PMID 25274008, Free PMC Article
    5. Lack of nAChR activity depresses cochlear maturation and up-regulates GABA system components: temporal profiling of gene expression in alpha9 null mice. Turcan S, et al. PLoS One, 2010 Feb 4. PMID 20140217, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
      Title: Alpha9alpha10 knockout mice show altered physiological and behavioral responses to signals in masking noise.
    2. Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
      Title: Expression of Chrna9 is regulated by Tbx3 in undifferentiated pluripotent stem cells.
    3. Efferent feedback controls bilateral auditory spontaneous activity.
      Title: Efferent feedback controls bilateral auditory spontaneous activity.
    4. Characterization of HA-tagged alpha9 and alpha10 nAChRs in the mouse cochlea.
      Title: Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.
    5. Attenuation in Nicotinic Acetylcholine Receptor alpha9 and alpha10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
      Title: Attenuation in Nicotinic Acetylcholine Receptor α9 and α10 Subunit Double Knock-Out Mice of Experimental Autoimmune Encephalomyelitis.
    6. nAChR containing the alpha9 subunit might be involved in the homeostasis of osteocytes and therefore in bone mass regulation.
      Title: Deletion of nicotinic acetylcholine receptor alpha9 in mice resulted in altered bone structure.
    7. A point mutation in the hair cell's Chrna9 leads to increased gating of the receptor and greatly elongates IPSCs.
      Title: A Gain-of-Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short-Term Synaptic Plasticity.
    8. Chrna9 is critical for efferent modulation of mammalian type II vestibular hair cells. Type II hair cells from alpha9-/- mice, fail to respond to ACh at all.
      Title: ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.
    9. we developed RgIA4, a peptide that exhibits high potency for both human and rodent a9a10 nAChRs, and was at least 1,000-fold more selective for a9a10 nAChRs vs. all other molecular targets tested, including opioid and GABAB receptors
      Title: Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
    10. This study demonstrated that Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.
      Title: Alpha-9 nicotinic acetylcholine receptors mediate hypothermic responses elicited by provocative motion in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylcholine-gated monoatomic cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neuronal acetylcholine receptor subunit alpha-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081104.2 → NP_001074573.1  neuronal acetylcholine receptor subunit alpha-9 isoform a

      See identical proteins and their annotated locations for NP_001074573.1

      Status: VALIDATED

      Source sequence(s)
      AC115293
      Consensus CDS
      CCDS39101.1
      UniProtKB/TrEMBL
      G3X8Z7
      Related
      ENSMUSP00000031108.7, ENSMUST00000031108.9
      Conserved Domains (3) summary
      TIGR00860
      Location:10 → 474
      LIC; Cation transporter family protein
      pfam02931
      Location:31 → 236
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:244 → 474
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001403681.1 → NP_001390610.1  neuronal acetylcholine receptor subunit alpha-9 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC115293

    3. NM_001403682.1 → NP_001390611.1  neuronal acetylcholine receptor subunit alpha-9 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC115293

    4. NM_001403683.1 → NP_001390612.1  neuronal acetylcholine receptor subunit alpha-9 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115293

    5. NM_001403684.1 → NP_001390613.1  neuronal acetylcholine receptor subunit alpha-9 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC115293

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      66092317..66134823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254389.1 → XP_030110249.1  neuronal acetylcholine receptor subunit alpha-9 isoform X3

      Conserved Domains (3) summary
      TIGR00860
      Location:2 → 405
      LIC; Cation transporter family protein
      cd03558
      Location:86 → 100
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1 → 168
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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