YTHDF1 YTH N6-methyladenosine RNA binding protein F1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: YTHDF1provided by HGNC
Official Full Name: YTH N6-methyladenosine RNA binding protein F1provided by HGNC
Primary source: HGNC:HGNC:15867
See related: Ensembl:ENSG00000149658 MIM:616529; AllianceGenome:HGNC:15867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DF1; C20orf21
Summary: Enables N6-methyladenosine-containing RNA reader activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Implicated in colorectal cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (63195429..63216131, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (65000752..65021443, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (61826781..61847483, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis.
Title: RUVBL1/2 Blockade Targets YTHDF1 Activity to Suppress m6A-Dependent Oncogenic Translation and Colorectal Tumorigenesis.
HIF-1alpha-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation.
Title: HIF-1α-induced expression of the m6A reader YTHDF1 inhibits the ferroptosis of nucleus pulposus cells by promoting SLC7A11 translation.
YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner.
Title: YTHDF1 regulates GID8-mediated glutamine metabolism to promote colorectal cancer progression in m6A-dependent manner.
YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
Title: YTHDF1 facilitates esophageal cancer progression via augmenting m6A-dependent TINAGL1 translation.
YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation.
Title: YTHDF1 promotes the osteolytic bone metastasis of breast cancer via inducing EZH2 and CDH11 translation.
KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
Title: KIAA1429 increases FOXM1 expression through YTHDF1-mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma.
YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
Title: YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
RBMS1 Coordinates with the m[6]A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Title: RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
YTHDF1 promotes the viability and self-renewal of glioma stem cells by enhancing LINC00900 stability.
Title: YTHDF1 promotes the viability and self‑renewal of glioma stem cells by enhancing LINC00900 stability.
YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS.
Title: YTHDF1-CLOCK axis contributes to pathogenesis of allergic airway inflammation through LLPS.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93642 (e-PCR)
- UniSTS:91190

RH80054 (e-PCR)
- UniSTS:90837

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IBA Inferred from Biological aspect of Ancestor more info
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
involved_in learning	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA destabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translational initiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of antigen processing and presentation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in stress granule assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: YTH domain-containing family protein 1

Names: DACA-1; YTH N(6)-methyladenosine RNA binding protein 1; YTH N6-methyladenosine RNA binding protein 1; YTH domain family 1; YTH domain family protein 1; YTH domain family, member 1; dermatomyositis associated with cancer putative autoantigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017798.4 → NP_060268.2 YTH domain-containing family protein 1

See identical proteins and their annotated locations for NP_060268.2

Status: VALIDATED

Source sequence(s)

BC003681, BC050284

Consensus CDS

CCDS13511.1

UniProtKB/Swiss-Prot

Q8N3G5, Q8TBT1, Q96AN4, Q96S57, Q9BTI7, Q9BYJ9, Q9NX79

UniProtKB/TrEMBL

B3KTL8

Related

ENSP00000359364.3, ENST00000370339.8

Conserved Domains (3) summary

pfam04146
Location:390 → 523

YTH; YT521-B-like domain

cl09930
Location:258 → 311

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

cl26464
Location:227 → 364

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000020.11 Reference GRCh38.p14 Primary Assembly

Range

63195429..63216131 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024451914.2 → XP_024307682.1 YTH domain-containing family protein 1 isoform X1

UniProtKB/TrEMBL

B4DT65

Conserved Domains (3) summary

pfam04146
Location:340 → 473

YTH; YT521-B-like domain

cl09930
Location:208 → 261

RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.

cl26464
Location:177 → 314

Atrophin-1; Atrophin-1 family