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    Aox3 aldehyde oxidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 71724, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Aox3provided by MGI
    Official Full Name
    aldehyde oxidase 3provided by MGI
    Primary source
    MGI:MGI:1918974
    See related
    Ensembl:ENSMUSG00000064294 AllianceGenome:MGI:1918974
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aoh1; Aoh2; 1200011D03Rik
    Summary
    Enables aldehyde oxidase activity; electron transfer activity; and molybdenum ion binding activity. Predicted to be involved in xenobiotic metabolic process. Located in cytosol. Is expressed in nasal cavity. Orthologous to human AOX3P (aldehyde oxidase 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 21.0), liver E18 (RPKM 16.2) and 5 other tissues See more
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    Genomic context

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    See Aox3 in Genome Data Viewer
    Location:
    1 C1.3; 1 28.96 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58152294..58241380)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58113135..58202221)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene shugoshin 2A Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene predicted gene, 24548 Neighboring gene aldehyde oxidase 4 Neighboring gene predicted gene 15759 Neighboring gene aldehyde oxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of crucial amino acids in mouse aldehyde oxidase 3 that determine substrate specificity. Mahro M, et al. PLoS One, 2013. PMID 24358164, Free PMC Article
    2. Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase. Vila R, et al. J Biol Chem, 2004 Mar 5. PMID 14665639
    3. The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity. Coelho C, et al. J Biol Chem, 2012 Nov 23. PMID 23019336, Free PMC Article
    4. Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression. Mahro M, et al. Drug Metab Dispos, 2011 Oct. PMID 21705476
    5. Cloning of the cDNAs coding for two novel molybdo-flavoproteins showing high similarity with aldehyde oxidase and xanthine oxidoreductase. Terao M, et al. J Biol Chem, 2000 Sep 29. PMID 10893244

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1.
      Title: Insights into the structural determinants of substrate specificity and activity in mouse aldehyde oxidases.
    2. AOX3 forms a homodimer and each monomer comprises three major domains involved in binding to the cofactors.
      Title: The first mammalian aldehyde oxidase crystal structure: insights into substrate specificity.
    3. The recombinant aldehyde oxidase 3 was expressed and purified in a 30% active form, whereas the native aldehyde oxidase 3 is 100% active.
      Title: Characterization and crystallization of mouse aldehyde oxidase 3: from mouse liver to Escherichia coli heterologous protein expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aldehyde oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molybdenum ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdopterin cofactor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde oxidase 3
    Names
    aldehyde oxidase 1
    aldehyde oxidase homolog 1
    aldehyde oxidase structural homolog 2
    azaheterocycle hydroxylase 3
    NP_076106.2
    XP_006496347.1
    XP_006496348.1
    XP_017167859.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023617.2 → NP_076106.2  aldehyde oxidase 3

      See identical proteins and their annotated locations for NP_076106.2

      Status: VALIDATED

      Source sequence(s)
      AC025116, AK004700, AK054065, AV275739, BB616838, BX633666
      Consensus CDS
      CCDS14969.1
      UniProtKB/Swiss-Prot
      B2RSI5, G3X982, Q8VI15
      UniProtKB/TrEMBL
      Q9ESH4
      Related
      ENSMUSP00000049391.8, ENSMUST00000040999.14
      Conserved Domains (6) summary
      TIGR02969
      Location:9 → 1334
      mam_aldehyde_ox; aldehyde oxidase
      smart01008
      Location:594 → 697
      Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
      pfam00941
      Location:239 → 419
      FAD_binding_5; FAD binding domain in molybdopterin dehydrogenase
      pfam01799
      Location:91 → 162
      Fer2_2; [2Fe-2S] binding domain
      pfam02738
      Location:709 → 1241
      Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
      pfam03450
      Location:426 → 530
      CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58152294..58241380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496285.4 → XP_006496348.1  aldehyde oxidase 3 isoform X2

      UniProtKB/TrEMBL
      Q9ESH4
      Conserved Domains (1) summary
      TIGR02969
      Location:1 → 1211
      mam_aldehyde_ox; aldehyde oxidase

    2. XM_006496284.5 → XP_006496347.1  aldehyde oxidase 3 isoform X1

      UniProtKB/TrEMBL
      Q9ESH4
      Conserved Domains (1) summary
      TIGR02969
      Location:1 → 1277
      mam_aldehyde_ox; aldehyde oxidase

    3. XM_017312370.3 → XP_017167859.1  aldehyde oxidase 3 isoform X3

      UniProtKB/TrEMBL
      Q9CW59
      Conserved Domains (1) summary
      TIGR02969
      Location:1 → 1110
      mam_aldehyde_ox; aldehyde oxidase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3X982.1 GenPept UniProtKB/Swiss-Prot:G3X982

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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