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    Nfic nuclear factor I/C [ Mus musculus (house mouse) ]

    Gene ID: 18029, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nficprovided by MGI
    Official Full Name
    nuclear factor I/Cprovided by MGI
    Primary source
    MGI:MGI:109591
    See related
    Ensembl:ENSMUSG00000055053 AllianceGenome:MGI:109591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NF1-C; 1110019L22Rik; 1500041O16Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Acts upstream of or within odontogenesis of dentin-containing tooth. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; retina nuclear layer; and skeletal musculature. Orthologous to human NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 27.2), lung adult (RPKM 13.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfic in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81232025..81267753, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81396191..81431919, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 48551 Neighboring gene predicted gene, 48552 Neighboring gene small integral membrane protein 24 Neighboring gene predicted gene 16104 Neighboring gene microRNA 1191b Neighboring gene predicted gene, 53593 Neighboring gene predicted gene, 51811 Neighboring gene STARR-positive B cell enhancer ABC_E577 Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene nicalin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription. Jia P, et al. Tissue Cell, 2023 Apr. PMID 36669387
    2. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Huang W, et al. Cell Death Dis, 2021 Dec 20. PMID 34930914, Free PMC Article
    3. Nuclear factor I-C is essential for odontogenic cell proliferation and odontoblast differentiation during tooth root development. Lee DS, et al. J Biol Chem, 2009 Jun 19. PMID 19386589, Free PMC Article
    4. Disruption of Nfic causes dissociation of odontoblasts by interfering with the formation of intercellular junctions and aberrant odontoblast differentiation. Lee TY, et al. J Histochem Cytochem, 2009 May. PMID 19153194, Free PMC Article
    5. Nfic gene disruption inhibits differentiation of odontoblasts responsible for root formation and results in formation of short and abnormal roots in mice. Park JC, et al. J Periodontol, 2007 Sep. PMID 17760551

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
      Title: NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.
    2. NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
      Title: NFIC attenuates rheumatoid arthritis-induced inflammatory response in mice by regulating PTEN/SENP8 transcription.
    3. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
      Title: Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
    4. Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
      Title: Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis.
    5. NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
      Title: NFI-C Is Required for Epiphyseal Chondrocyte Proliferation during Postnatal Cartilage Development.
    6. the Runx2-Nfic-Osx pathway is one of the key factors that regulate ameloblast differentiation.
      Title: The Nfic-osterix pathway regulates ameloblast differentiation and enamel formation.
    7. An Nfic-Hhip-Hh signaling pathway is crucial for apical papilla growth and proper root formation.
      Title: An Nfic-hedgehog signaling cascade regulates tooth root development.
    8. NFI-C acts as a regulator of the phased hepatocyte proliferation during liver regeneration.
      Title: Nuclear Factor I-C acts as a regulator of hepatocyte proliferation at the onset of liver regeneration.
    9. Results suggest that NFI-C acts as a transcriptional switch in cell fate determination between osteoblast and adipocyte differentiation in BMSCs.
      Title: NFI-C regulates osteoblast differentiation via control of osterix expression.
    10. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-beta1 signaling in mouse odontoblasts.
      Title: Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor 1 C-type
    Names
    CCAAT-box-binding transcription factor
    CTF
    NF-I/C
    NFI-C
    TGGCA-binding protein
    nuclear factor 1-C2
    nuclear factor 1/C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008688.3 → NP_032714.1  nuclear factor 1 C-type isoform a

      See identical proteins and their annotated locations for NP_032714.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes a longer isoform (a).
      Source sequence(s)
      AC155937, AK087539, BY226699
      Consensus CDS
      CCDS24058.1
      UniProtKB/Swiss-Prot
      O09072, P70255, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3
      UniProtKB/TrEMBL
      A0A1Y7VK55
      Related
      ENSMUSP00000020461.9, ENSMUST00000020461.15
      Conserved Domains (3) summary
      pfam00859
      Location:217 → 424
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:10 → 47
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:68 → 169
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. NM_026756.2 → NP_081032.2  nuclear factor 1 C-type isoform b

      See identical proteins and their annotated locations for NP_081032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate penultimate exon, resulting in a novel 3' coding region and shorter 3' UTR, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC155937, AK147496, BY226699
      Consensus CDS
      CCDS35999.1
      UniProtKB/TrEMBL
      A0A1Y7VK55, Q3UHA6
      Related
      ENSMUSP00000100958.4, ENSMUST00000105321.10
      Conserved Domains (3) summary
      pfam00859
      Location:217 → 423
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:10 → 47
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:68 → 169
      MH1; N-terminal Mad Homology 1 (MH1) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81232025..81267753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244940.1 → XP_030100800.1  nuclear factor 1 C-type isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VK55
      Conserved Domains (3) summary
      pfam00859
      Location:208 → 414
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 164
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. XM_006513335.4 → XP_006513398.1  nuclear factor 1 C-type isoform X1

      See identical proteins and their annotated locations for XP_006513398.1

      UniProtKB/TrEMBL
      A0A1Y7VK55
      Related
      ENSMUSP00000113046.2, ENSMUST00000117966.2
      Conserved Domains (3) summary
      pfam00859
      Location:208 → 415
      CTF_NFI; CTF/NF-I family transcription modulation region
      pfam10524
      Location:2 → 38
      NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
      cl00055
      Location:60 → 164
      MH1; N-terminal Mad Homology 1 (MH1) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70255.1 GenPept UniProtKB/Swiss-Prot:P70255

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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