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    Slc17a1 solute carrier family 17 (sodium phosphate), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20504, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Slc17a1provided by MGI
    Official Full Name
    solute carrier family 17 (sodium phosphate), member 1provided by MGI
    Primary source
    MGI:MGI:103209
    See related
    Ensembl:ENSMUSG00000021335 AllianceGenome:MGI:103209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npt1; Napi1; NAPI-1
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in several processes, including sodium-dependent phosphate transport; urate metabolic process; and urate transport. Predicted to be active in apical plasma membrane. Is expressed in cortical renal tubule and lower jaw molar. Orthologous to human SLC17A1 (solute carrier family 17 member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 67.9) See more
    Orthologs
    human all
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    Genomic context

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    See Slc17a1 in Genome Data Viewer
    Location:
    13 A3.1; 13 9.97 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24051607..24079713)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23867624..23895730)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 17 (sodium phosphate), member 2 Neighboring gene solute carrier family 17 (sodium phosphate), member 3 Neighboring gene solute carrier family 17 (sodium phosphate), member 4 Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assignment of renal specific Na(+)-phosphate cotransporter gene Slc17a1 to mouse chromosome bands 13A3-->A4 by in situ hybridization. Zhang XX, et al. Cytogenet Cell Genet, 1997. PMID 9186516
    2. Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse. Kraus T, et al. Neurosci Lett, 2004 Apr 22. PMID 15082177
    3. SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Li VL, et al. Nat Commun, 2024 Aug 12. PMID 39134528, Free PMC Article
    4. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Chong SS, et al. Genomics, 1993 Nov. PMID 8288239
    5. Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit. Kos CH, et al. Cytogenet Cell Genet, 1996. PMID 8995482

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
      Title: Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.
    2. Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
      Title: Subtype switching of vesicular glutamate transporters at parallel fibre-Purkinje cell synapses in developing mouse cerebellum.
    3. The finding of VGLUT1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles may reflect differences in functional properties and the embryonic origin between skeletal and esophageal striated muscle fibers.
      Title: Vesicular glutamate transporter 1 immunoreactivity in motor endplates of striated esophageal but not skeletal muscles in the mouse.
    4. Mossy terminals are immunoreactive for VGLUT1 and mGluR1alpha dendritic brushes are immunopositive for VGLUT1 in organotypic cultures of mouse vestibulocerebellum.
      Title: Vesicular glutamate transporters VGLUT1 and VGLUT2 define two subsets of unipolar brush cells in organotypic cultures of mouse vestibulocerebellum.
    5. Data show that hepatocyte nuclear factor 1 alpha (HNF1alpha) directly transactivates the Npt1 promoter and that the HSS3 region contributes to this activation.
      Title: Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-dependent phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium-dependent phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium-dependent phosphate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in urate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transport protein 1
    Names
    Na(+)/PI cotransporter 1
    renal Na(+)-dependent phosphate cotransporter 1
    renal sodium-phosphate transport protein 1
    sodium-dependent phosphate/anion cotransporter
    sodium/phosphate type I cotransporter
    solute carrier family 17 (sodium/hydrogen exchanger), member 1
    solute carrier family 17 vesicular glutamate transporter), member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170638.1 → NP_001164109.1  sodium-dependent phosphate transport protein 1

      See identical proteins and their annotated locations for NP_001164109.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA986929, AI663290, AK132800, AK164712, AW261800, CJ065843
      Consensus CDS
      CCDS26372.1
      UniProtKB/Swiss-Prot
      A9Z1Z4, Q61983, Q91YA1
      UniProtKB/TrEMBL
      Q91WV5
      Related
      ENSMUSP00000106043.2, ENSMUST00000110413.8
      Conserved Domains (2) summary
      cd06174
      Location:71 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:1 → 464
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. NM_009198.3 → NP_033224.3  sodium-dependent phosphate transport protein 1

      See identical proteins and their annotated locations for NP_033224.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the protein. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA986929, AI116499, AI663290, AK132800, AK164712, AW261800, CJ065843
      Consensus CDS
      CCDS26372.1
      UniProtKB/Swiss-Prot
      A9Z1Z4, Q61983, Q91YA1
      UniProtKB/TrEMBL
      Q91WV5
      Related
      ENSMUSP00000006785.8, ENSMUST00000006785.8
      Conserved Domains (2) summary
      cd06174
      Location:71 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00894
      Location:1 → 464
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RNA

    1. NR_121611.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI663290, AK132800, AK164712, AL590388, AL606464

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      24051607..24079713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516616.4 → XP_006516679.1  sodium-dependent phosphate transport protein 1 isoform X1

      UniProtKB/TrEMBL
      Q91WV5
      Conserved Domains (1) summary
      TIGR00894
      Location:34 → 497
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    2. XM_006516617.2 → XP_006516680.1  sodium-dependent phosphate transport protein 1 isoform X2

      UniProtKB/TrEMBL
      Q91WV5
      Conserved Domains (1) summary
      TIGR00894
      Location:1 → 376
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61983.2 GenPept UniProtKB/Swiss-Prot:Q61983

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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