Rrm1 ribonucleotide reductase M1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rrm1provided by MGI
Official Full Name: ribonucleotide reductase M1provided by MGI
Primary source: MGI:MGI:98180
See related: Ensembl:ENSMUSG00000030978 AllianceGenome:MGI:98180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RnrM1
Summary: Enables disordered domain specific binding activity; purine nucleotide binding activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including nucleoside phosphate metabolic process; positive regulation of G0 to G1 transition; and protein heterotetramerization. Part of ribonucleoside-diphosphate reductase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 64.2), liver E14.5 (RPKM 56.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 54.72 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (102090902..102118978)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (102441695..102469771)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provides an improved understanding of the molecular basis (structure and dynamics) that governs the binding of the p54(nrb)/NonO RRM1 to one of its target RNAs.
Title: Structure, Dynamics, and Interaction of p54(nrb)/NonO RRM1 with 5' Splice Site RNA Sequence.
This work reveals that binding of RRM1 to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
Title: A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 and Rrm2 improves cardiac performance
Title: Transgenic overexpression of ribonucleotide reductase improves cardiac performance.
silencing RRM1 expression using siRNA could potentially be an effective strategy to overcome gemcitabine resistance.
Title: Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells.
Tip60-dependent recruitment of RNR plays an essential role in dNTP supply for DNA repair
Title: Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.
overexpression of RRM1 in human and mouse lung cancer cell lines induced PTEN expression, reduced phosphorylation of focal adhesion kinase (FAK), suppressed migration, invasion, and metastasis formation, and increased survival in an animal model.
Title: RRM1-induced metastasis suppression through PTEN-regulated pathways.
The hexamer form of murine ribonucleotide reductase (mRR) large catalytic subunit mR1(6) predominates over the dimer form mR1(2) in the cytoplasm of normal cells, where the great majority of mRR activity is located.
Title: Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rrm1 (e-PCR), detects polymorphism
- UniSTS:507201

K02927 (e-PCR)
- UniSTS:159672

px-59h6 (e-PCR)
- UniSTS:257996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables purine nucleotide binding	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside-diphosphate reductase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 2'-deoxyribonucleotide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in DNA synthesis involved in DNA repair	NAS Non-traceable Author Statement more info	PubMed
involved_in cell proliferation in forebrain	IEA Inferred from Electronic Annotation more info
involved_in deoxyribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyribonucleotide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial DNA replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G0 to G1 transition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	IPI Inferred from Physical Interaction more info	PubMed
involved_in pyrimidine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to ionizing radiation	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in ribonucleoside diphosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ribonucleoside diphosphate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of ribonucleoside-diphosphate reductase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoside-diphosphate reductase complex	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ribonucleoside-diphosphate reductase complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoside-diphosphate reductase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribonucleoside-diphosphate reductase large subunit

Names: ribonucleoside-diphosphate reductase subunit M1; ribonucleotide reductase large subunit

NP_033129.2

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009103.3 → NP_033129.2 ribonucleoside-diphosphate reductase large subunit

See identical proteins and their annotated locations for NP_033129.2

Status: VALIDATED

Source sequence(s)

AC102535, AK168586

Consensus CDS

CCDS40049.1

UniProtKB/Swiss-Prot

P07742, Q91YM8

UniProtKB/TrEMBL

Q6NZB3

Related

ENSMUSP00000033283.10, ENSMUST00000033283.10

Conserved Domains (3) summary

cd01679
Location:167 → 741

RNR_I; Class I ribonucleotide reductase

PLN02437
Location:1 → 792

PLN02437; ribonucleoside--diphosphate reductase large subunit

pfam03477
Location:1 → 89

ATP-cone; ATP cone domain