Iqgap2 IQ motif containing GTPase activating protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Iqgap2provided by MGI
Official Full Name: IQ motif containing GTPase activating protein 2provided by MGI
Primary source: MGI:MGI:2449975
See related: Ensembl:ENSMUSG00000021676 AllianceGenome:MGI:2449975
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A630053O10; 4933417J23Rik
Summary: Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in actin filament organization; regulation of actin cytoskeleton organization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in placenta adult (RPKM 18.9), liver E18 (RPKM 15.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 50.26 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (95763685..96028788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (95627177..95892280, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
Title: Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling.
The exacerbated mast cell responses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by down-modulation of Dnmt1 expression. These effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2.
Title: Dnmt3a restrains mast cell inflammatory responses.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2
Title: Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci.
Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS)-induced colitis.
Title: IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
Title: Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma.
Phosphoinositide module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)).
Title: IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold.
murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo
Title: Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake.
Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent.
Title: Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

F2rl2 (e-PCR), detects polymorphism
- UniSTS:525906

Iqgap2 (e-PCR), detects polymorphism
- UniSTS:498268

MARC_17727-17728:1031758304:1 (e-PCR)
- UniSTS:268387

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

F2rl2 (e-PCR), detects polymorphism
- UniSTS:536431

D13Mit320 (e-PCR), detects polymorphism
- UniSTS:141937

AI788777 (e-PCR)
- UniSTS:164533

Iqgap2 (e-PCR), detects polymorphism
- UniSTS:256441

D13Mit145 (e-PCR), detects polymorphism
- UniSTS:126968

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Arp2/3 complex binding	IEA Inferred from Electronic Annotation more info
enables Arp2/3 complex binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027711.1 → NP_081987.1 ras GTPase-activating-like protein IQGAP2

See identical proteins and their annotated locations for NP_081987.1

Status: VALIDATED

Source sequence(s)

AK142813, AK147360, CJ201339

Consensus CDS

CCDS36753.1

UniProtKB/Swiss-Prot

Q3UQ44

UniProtKB/TrEMBL

B9EKK3

Related

ENSMUSP00000067685.7, ENSMUST00000068603.8

Conserved Domains (5) summary

smart00015
Location:689 → 710

IQ; Calmodulin-binding motif

cd05131
Location:916 → 1274

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

smart00323
Location:905 → 1257

RasGAP; GTPase-activator protein for Ras-like GTPases

cd00014
Location:42 → 156

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam03836
Location:1367 → 1498

RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

95763685..96028788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158092.1 → XP_036013985.1 ras GTPase-activating-like protein IQGAP2 isoform X2

UniProtKB/TrEMBL

B9EKK3

Conserved Domains (4) summary

smart00015
Location:726 → 747

IQ; Calmodulin-binding motif

cd05131
Location:953 → 1311

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

COG5261
Location:821 → 1606

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cl00030
Location:53 → 203

CH_SF; calponin homology (CH) domain superfamily
XM_036158091.1 → XP_036013984.1 ras GTPase-activating-like protein IQGAP2 isoform X1

UniProtKB/TrEMBL

B9EKK3

Conserved Domains (4) summary

smart00015
Location:726 → 747

IQ; Calmodulin-binding motif

cd05131
Location:953 → 1311

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

COG5261
Location:821 → 1612

IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]

cl00030
Location:53 → 203

CH_SF; calponin homology (CH) domain superfamily