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    Anp32a acidic nuclear phosphoprotein 32 family member A [ Mus musculus (house mouse) ]

    Gene ID: 11737, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Anp32aprovided by MGI
    Official Full Name
    acidic nuclear phosphoprotein 32 family member Aprovided by MGI
    Primary source
    MGI:MGI:108447
    See related
    Ensembl:ENSMUSG00000032249 AllianceGenome:MGI:108447
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LANP; pp32; Anp32; PHAP1; I1PP2A
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Located in nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 178.7), CNS E14 (RPKM 62.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Anp32a in Genome Data Viewer
    Location:
    9 B; 9 33.68 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62248637..62286084)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62341343..62378804)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S16 pseudogene Neighboring gene predicted gene, 35288 Neighboring gene STARR-seq mESC enhancer starr_24372 Neighboring gene STARR-positive B cell enhancer ABC_E6749 Neighboring gene predicted gene, 20346 Neighboring gene predicted gene, 40522 Neighboring gene STARR-seq mESC enhancer starr_24378 Neighboring gene VISTA enhancer mm210 Neighboring gene predicted gene, 40523

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Generation and characterization of LANP/pp32 null mice. Opal P, et al. Mol Cell Biol, 2004 Apr. PMID 15060138, Free PMC Article
    2. PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A. Zhang M, et al. J Virol, 2024 Mar 19. PMID 38421166, Free PMC Article
    3. The expression and distributions of ANP32A in the developing brain. Wang S, et al. Biomed Res Int, 2015. PMID 25866766, Free PMC Article
    4. Low Polymerase Activity Attributed to PA Drives the Acquisition of the PB2 E627K Mutation of H7N9 Avian Influenza Virus in Mammals. Liang L, et al. mBio, 2019 Jun 18. PMID 31213560, Free PMC Article
    5. Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits. Chai GS, et al. J Alzheimers Dis, 2018. PMID 29782322

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
      Title: PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
    2. Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
      Title: Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
    3. Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
      Title: Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
    4. ANP32A/ATM axis discovered in cartilage is also present in brain and bone.
      Title: ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.
    5. The findings of this study reveal that upregulated ANP32A induced-suppressing histone acetylation may underlie the cognitive decline in neurodegenerative disease.
      Title: Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits.
    6. our study reveals that ANP32A dysregulation may be a critical factor contributing to acute megakaryoblastic leukemia
      Title: ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.
    7. We conclude that downregulating ANP32A rescues synaptic plasticity and memory ability by reducing INHAT formation and unmasking histone for hyperacetylation
      Title: Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.
    8. The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development
      Title: The expression and distributions of ANP32A in the developing brain.
    9. depleting the Leucine-rich Acidic Nuclear Protein (LANP)-an ATXN1 binding inhibitor of histone acetylation-reverses aspects of Spinocerebellar ataxia type 1 neuritic pathology.
      Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
    10. LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels
      Title: Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acidic leucine-rich nuclear phosphoprotein 32 family member A
    Names
    acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
    acidic nuclear phosphoprotein 32
    acidic nuclear phosphoprotein pp32
    leucine-rich acidic nuclear protein
    potent heat-stable protein phosphatase 2A inhibitor I1PP2A
    vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411151.1 → NP_001398080.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113291, AC121813

    2. NM_001411152.1 → NP_001398081.1  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113291, AC121813
      UniProtKB/TrEMBL
      D3Z7M9
      Related
      ENSMUSP00000122165.2, ENSMUST00000135395.8

    3. NM_009672.4 → NP_033802.2  acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1

      See identical proteins and their annotated locations for NP_033802.2

      Status: VALIDATED

      Source sequence(s)
      AC113291, AC121813
      Consensus CDS
      CCDS40663.1
      UniProtKB/Swiss-Prot
      O35381, P97437
      Related
      ENSMUSP00000082652.7, ENSMUST00000085519.13
      Conserved Domains (3) summary
      sd00035
      Location:90 → 113
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam14580
      Location:71 → 146
      LRR_9; Leucine-rich repeat
      NF033189
      Location:9 → 128
      internalin_A; class 1 internalin InlA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      62248637..62286084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35381.1 GenPept UniProtKB/Swiss-Prot:O35381

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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