Rab4a RAB4A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab4aprovided by MGI
Official Full Name: RAB4A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:105069
See related: Ensembl:ENSMUSG00000019478 AllianceGenome:MGI:105069
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab4
Summary: Predicted to enable several functions, including ATPase binding activity; guanyl ribonucleotide binding activity; and ionotropic glutamate receptor binding activity. Involved in neurotransmitter receptor transport postsynaptic membrane to endosome and vesicle-mediated transport in synapse. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in endosome. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver and biliary system; and primitive endoderm. Orthologous to human RAB4A (RAB4A, member RAS oncogene family). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 26.3), cerebellum adult (RPKM 22.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 72.19 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (124532748..124562030)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (123805846..123835291)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Title: Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.
Insulin-dependent Rab4a redistribution, probably reflecting stimulation of vesicle-mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL-6, IL-8, or IL-15.
Title: Insulin-dependent cytoplasmic distribution of Rab4a in mouse adipocytes is inhibited by interleukin-6, -8, and -15.
Reduced Akt2 leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha.
Title: Akt2 deficiency promotes cardiac induction of Rab4a and myocardial β-adrenergic hypersensitivity.
Sorting of PDGF beta-receptors on early endosomes is regulated by sequential activation of PKCalpha and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.
Title: Activation of protein kinase C alpha is necessary for sorting the PDGF beta-receptor to Rab4a-dependent recycling.
p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase cycles of Rab5 and Rab4
Title: The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins.
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Title: The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes
Title: Enhancement of the recycling and activation of beta-adrenergic receptor by Rab4 GTPase in cardiac myocytes.
insulin signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 with microtubules and this process is mediated by insulin-induced PI3-kinase-dependent PKC-lambda activation and participates in GLUT4 exocytosis
Title: Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI848268 (e-PCR)
- UniSTS:179851

RH127889 (e-PCR)
- UniSTS:211199

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Rab protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in insulin-responsive compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in insulin-responsive compartment	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-4A

NP_033029.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.