arhgef12a Rho guanine nucleotide exchange factor (GEF) 12a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: arhgef12aprovided by ZNC
Official Full Name: Rho guanine nucleotide exchange factor (GEF) 12aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-121017-3
See related: Ensembl:ENSDARG00000030532 AllianceGenome:ZFIN:ZDB-GENE-121017-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: arhgef12
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within erythrocyte differentiation. Predicted to be located in cytoplasm and membrane. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (22446322..22537374)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (22510386..22601640)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj54b05.x1 (e-PCR)
- UniSTS:188677

G47212 (e-PCR)
- UniSTS:107997

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 12

Names: Rho guanine nucleotide exchange factor (GEF) 12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

22446322..22537374

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291731.4 → XP_009290006.1 rho guanine nucleotide exchange factor 12 isoform X1

UniProtKB/TrEMBL

A0A8M3AHH6, E7FDV8

Related

ENSDARP00000040541.5, ENSDART00000040542.7

Conserved Domains (4) summary

cd00992
Location:66 → 140

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00621
Location:743 → 928

RhoGEF; RhoGEF domain

cl02565
Location:308 → 524

RGS; Regulator of G protein signaling (RGS) domain superfamily

cl17171
Location:947 → 1083

PH-like; Pleckstrin homology-like domain
XM_009291733.4 → XP_009290008.1 rho guanine nucleotide exchange factor 12 isoform X3

UniProtKB/TrEMBL

A0A2R8QD00, A0A8M3AIL3

Related

ENSDARP00000149601.1, ENSDART00000190270.1

Conserved Domains (4) summary

cd00992
Location:47 → 121

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00621
Location:724 → 909

RhoGEF; RhoGEF domain

cl02565
Location:289 → 505

RGS; Regulator of G protein signaling (RGS) domain superfamily

cl17171
Location:928 → 1064

PH-like; Pleckstrin homology-like domain
XM_068213719.1 → XP_068069820.1 rho guanine nucleotide exchange factor 12 isoform X2

Related

ENSDARP00000152634.1, ENSDART00000185897.1