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    c6ast1 six-cysteine containing astacin protease 1 [ Danio rerio (zebrafish) ]

    Gene ID: 751088, updated on 2-Nov-2024

    Summary

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    Official Symbol
    c6ast1provided by ZNC
    Official Full Name
    six-cysteine containing astacin protease 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070621-1
    See related
    Ensembl:ENSDARG00000069216 AllianceGenome:ZFIN:ZDB-GENE-070621-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zc6ast1
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to act upstream of or within proteolysis. Orthologous to human ASTL (astacin like metalloendopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See c6ast1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38661870..38664947, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38390612..38393689, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene six-cysteine containing astacin protease 3 Neighboring gene nephrosin Neighboring gene mitochondrial carrier homolog 2 Neighboring gene proteasome 26S subunit, ATPase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of teleostean hatching enzyme genes and their paralogous genes. Kawaguchi M, et al. Dev Genes Evol, 2006 Dec. PMID 17016731
    2. The seahorse genome and the evolution of its specialized morphology. Lin Q, et al. Nature, 2016 Dec 14. PMID 27974754, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    six-cysteine containing astacin protease 1
    Names
    astacin like metallo-protease
    NP_001036784.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001043319.1 → NP_001036784.1  six-cysteine containing astacin protease 1 precursor

      See identical proteins and their annotated locations for NP_001036784.1

      Status: PROVISIONAL

      Source sequence(s)
      AB256952
      UniProtKB/TrEMBL
      A0A8M1N8X0, Q14TH1
      Related
      ENSDARP00000091319.4, ENSDART00000100546.6
      Conserved Domains (2) summary
      cd04283
      Location:77 → 257
      ZnMc_hatching_enzyme; Zinc-dependent metalloprotease, hatching enzyme-like subfamily. Hatching enzymes are secreted by teleost embryos to digest the egg envelope or chorion. In some teleosts, the hatching enzyme may be a system consisting of two evolutionary related ...
      pfam01400
      Location:71 → 259
      Astacin; Astacin (Peptidase family M12A)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      38661870..38664947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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