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    magi1b membrane associated guanylate kinase, WW and PDZ domain containing 1b [ Danio rerio (zebrafish) ]

    Gene ID: 474349, updated on 10-Sep-2024

    Summary

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    Official Symbol
    magi1bprovided by ZNC
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5110
    See related
    Ensembl:ENSDARG00000003169 AllianceGenome:ZFIN:ZDB-GENE-030131-5110
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    magi1; MAGI-1; baiap1; fe48b06; wu:fe48b06; wu:fj98f08
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in signal transduction. Predicted to be located in bicellular tight junction and membrane. Predicted to be active in cell-cell junction and cytoplasm. Is expressed in blastoderm. Orthologous to human MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18873096..19090812)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18710760..18928462)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b Neighboring gene putative homeodomain transcription factor 1 Neighboring gene rhodopsin, like Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish. Aanes H, et al. BMC Genomics, 2013 May 15. PMID 23676078, Free PMC Article
    2. Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. Herrero-Turrión MJ, et al. BMC Genomics, 2014 Oct 8. PMID 25294025, Free PMC Article
    3. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Wright GJ, et al. Development, 2004 Nov. PMID 15509766
    4. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    5. Analysis and functional evaluation of the hair-cell transcriptome. McDermott BM Jr, et al. Proc Natl Acad Sci U S A, 2007 Jul 10. PMID 17606911, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b
    Names
    BAI1-associated protein 1
    membrane associated guanylate kinase, WW and PDZ domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007063.2 → NP_001007064.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1b

      Status: VALIDATED

      Source sequence(s)
      AL935040, BX294166, CR932038
      UniProtKB/TrEMBL
      A0A8M1N2L7, F1QZB9
      Related
      ENSDARP00000094744.5, ENSDART00000103969.6

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      18873096..19090812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155831.4 → XP_005155888.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8M2B2I9
      Conserved Domains (8) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:473 → 554
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:984 → 1067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam08648
      Location:1341 → 1444
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:1357 → 1441
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16666
      Location:726 → 818
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    2. XM_009305956.3 → XP_009304231.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8M3AXK8
      Conserved Domains (6) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:473 → 554
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:984 → 1079
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam16666
      Location:726 → 818
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    3. XM_005155829.4 → XP_005155886.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B284
      Conserved Domains (8) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:473 → 554
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:984 → 1079
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam08648
      Location:1353 → 1456
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:1369 → 1453
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16666
      Location:726 → 818
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    4. XM_005155830.4 → XP_005155887.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2Q4
      Conserved Domains (8) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:473 → 554
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:982 → 1077
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam08648
      Location:1351 → 1454
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:1367 → 1451
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16666
      Location:726 → 816
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    5. XM_009305951.3 → XP_009304226.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M3AXI7
      Conserved Domains (8) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:467 → 548
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:978 → 1073
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam08648
      Location:1347 → 1450
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:1363 → 1447
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16666
      Location:720 → 812
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    6. XM_009305953.3 → XP_009304228.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8M3B402
      Conserved Domains (8) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:428 → 509
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:939 → 1034
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361 → 390
      WW; WW domain
      pfam08648
      Location:1308 → 1411
      DUF1777; Protein of unknown function (DUF1777)
      pfam12871
      Location:1324 → 1408
      PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
      pfam16666
      Location:681 → 773
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    7. XM_021479602.1 → XP_021335277.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9PUV4
      Conserved Domains (9) summary
      smart00456
      Location:301 → 332
      WW; Domain with 2 conserved Trp (W) residues
      smart00228
      Location:461 → 542
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:972 → 1067
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349 → 378
      WW; WW domain
      pfam08648
      Location:1349 → 1437
      DUF1777; Protein of unknown function (DUF1777)
      pfam16663
      Location:197 → 256
      MAGI_u1; Unstructured region on MAGI
      pfam16666
      Location:714 → 806
      MAGI_u5; Unstructured region on MAGI
      cl17190
      Location:117 → 242
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
      cl28033
      Location:1217 → 1530
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    8. XM_005155835.4 → XP_005155892.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8M2B1V1
      Conserved Domains (4) summary
      cd00992
      Location:277 → 372
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08648
      Location:646 → 749
      DUF1777; Protein of unknown function (DUF1777)
      pfam15670
      Location:688 → 738
      Spem1; Spermatid maturation protein 1
      pfam16666
      Location:21 → 111
      MAGI_u5; Unstructured region on MAGI

    9. XM_005155834.4 → XP_005155891.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8M2B1Z1
      Conserved Domains (4) summary
      cd00992
      Location:282 → 377
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08648
      Location:651 → 754
      DUF1777; Protein of unknown function (DUF1777)
      pfam15670
      Location:693 → 743
      Spem1; Spermatid maturation protein 1
      pfam16666
      Location:25 → 116
      MAGI_u5; Unstructured region on MAGI
    Nucleotide Protein
    Heading Accession and Version

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