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    nln neurolysin (metallopeptidase M3 family) [ Danio rerio (zebrafish) ]

    Gene ID: 449659, updated on 28-Oct-2024

    Summary

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    Official Symbol
    nlnprovided by ZNC
    Official Full Name
    neurolysin (metallopeptidase M3 family)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-216
    See related
    Ensembl:ENSDARG00000019233 AllianceGenome:ZFIN:ZDB-GENE-041010-216
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92589
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and proteolysis. Predicted to be active in mitochondrial intermembrane space. Is expressed in hypaxial myotome region; musculature system; myotome; and pectoral fin musculature. Orthologous to human NLN (neurolysin). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nln in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (15408590..15447586)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (15450453..15489467)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene pumilio RNA-binding family member 3 Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene small glutamine rich tetratricopeptide repeat co-chaperone beta Neighboring gene erbb2 interacting protein Neighboring gene zinc finger, AN1-type domain 5b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Neurotensin Enhances Locomotor Activity and Arousal and Inhibits Melanin-Concentrating Hormone Signaling. Levitas-Djerbi T, et al. Neuroendocrinology, 2020. PMID 31030196
    2. A reference growth curve for nutritional experiments in zebrafish (Danio rerio) and changes in whole body proteome during development. Gómez-Requeni P, et al. Fish Physiol Biochem, 2010 Dec. PMID 20432063
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurolysin, mitochondrial
    NP_001005930.1
    XP_005155624.1
    XP_005155626.1
    XP_017213448.1
    XP_068079877.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005930.1 → NP_001005930.1  neurolysin, mitochondrial

      See identical proteins and their annotated locations for NP_001005930.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083527
      UniProtKB/TrEMBL
      Q5XIZ1
      Related
      ENSDARP00000015197.9, ENSDART00000003839.11
      Conserved Domains (2) summary
      cd06455
      Location:60 → 648
      M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
      COG0339
      Location:50 → 650
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      15408590..15447586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155567.5 → XP_005155624.1  neurolysin, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A2R8RVE2, A0A8M2B1S5
      Related
      ENSDARP00000153706.1, ENSDART00000192395.1
      Conserved Domains (2) summary
      cd06455
      Location:60 → 698
      M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
      COG0339
      Location:50 → 700
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. XM_068223776.1 → XP_068079877.1  neurolysin, mitochondrial isoform X2

      Related
      ENSDARP00000108339.3, ENSDART00000123818.4

    3. XM_005155569.4 → XP_005155626.1  neurolysin, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8M2B1N0
      Conserved Domains (2) summary
      cd06455
      Location:37 → 675
      M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
      COG0339
      Location:27 → 677
      Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

    4. XM_017357959.3 → XP_017213448.1  neurolysin, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A8M6Z2X4
    Nucleotide Protein
    Heading Accession and Version

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