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    rad1 RAD1 homolog (S. pombe) [ Danio rerio (zebrafish) ]

    Gene ID: 393872, updated on 12-Sep-2024

    Summary

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    Official Symbol
    rad1provided by ZNC
    Official Full Name
    RAD1 homolog (S. pombe)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1873
    See related
    Ensembl:ENSDARG00000040559 AllianceGenome:ZFIN:ZDB-GENE-040426-1873
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56502; zgc:77779
    Summary
    Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in DNA damage checkpoint signaling and DNA repair. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rad1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23780499..23784518, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23845234..23849253, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene BCL2 binding component 3 Neighboring gene intraflagellar transport 20 homolog (Chlamydomonas) Neighboring gene transmembrane protein 97 Neighboring gene si:ch211-167j9.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77779

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables double-stranded DNA 3'-5' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA damage checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of checkpoint clamp complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell cycle checkpoint protein RAD1
    NP_957192.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200898.1 → NP_957192.1  cell cycle checkpoint protein RAD1

      See identical proteins and their annotated locations for NP_957192.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064305
      UniProtKB/TrEMBL
      A0A8M1PI65, Q6P2T4
      Related
      ENSDARP00000059353.5, ENSDART00000059354.6
      Conserved Domains (2) summary
      cd00577
      Location:18 → 275
      PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
      pfam02144
      Location:15 → 256
      Rad1; Repair protein Rad1/Rec1/Rad17

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      23780499..23784518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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