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    SFTPB surfactant protein B [ Bos taurus (domestic cattle) ]

    Gene ID: 507398, updated on 4-Oct-2024

    Summary

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    Official Symbol
    SFTPBprovided by VGNC
    Official Full Name
    surfactant protein Bprovided by VGNC
    Primary source
    VGNC:VGNC:34528
    See related
    BGD:BT10343; Ensembl:ENSBTAG00000021230
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See SFTPB in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 11 NC_037338.1 (49329784..49340737)

    Chromosome 11 - NC_037338.1Genomic Context describing neighboring genes Neighboring gene granulysin Neighboring gene uncharacterized LOC616323 Neighboring gene ubiquitin specific peptidase 39 Neighboring gene chromosome 11 C2orf68 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037338.1 Chromosome 11 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Orientation and depth of surfactant protein B C-terminal helix in lung surfactant bilayers. Bertani P, et al. Biochim Biophys Acta, 2012 May. PMID 22252270
    2. Modification of tryptophan and methionine residues is implicated in the oxidative inactivation of surfactant protein B. Manzanares D, et al. Biochemistry, 2007 May 8. PMID 17425286
    3. Hydrophobic surfactant proteins induce a phosphatidylethanolamine to form cubic phases. Chavarha M, et al. Biophys J, 2010 Apr 21. PMID 20409474, Free PMC Article
    4. Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids. Hite RD, et al. Am J Physiol Lung Cell Mol Physiol, 2012 Jan 15. PMID 22037357, Free PMC Article
    5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Measurements of the depth of SP-B(CTERM) indicated the peptide center positions ~8A more deeply than the phosphate headgroups, a topology that may allow the peptide to promote functional lipid structures without causing micellization upon compression.
      Title: Orientation and depth of surfactant protein B C-terminal helix in lung surfactant bilayers.
    2. results suggest the hydrophobic surfactant protein, SP-B, protects alveolar surfactant phospholiopids from hydrolysis mediated by multiple sPLA(2) in both vesicles (alveolar subphase) and monomolecular films (air-liquid interface)
      Title: Surfactant protein B inhibits secretory phospholipase A2 hydrolysis of surfactant phospholipids.
    3. The hydrophobic surfactant proteins SP-B and SP-C induce formation of bicontinuous inverse cubic phases.
      Title: Hydrophobic surfactant proteins induce a phosphatidylethanolamine to form cubic phases.
    4. Reactive oxygen species inactivation of lipid extract surfactant B (SP-B) biophysical activity appears to involve modification of a maximum of three amino acids: Trp9, Met29, and Met65.
      Title: Modification of tryptophan and methionine residues is implicated in the oxidative inactivation of surfactant protein B.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC140803

    Gene Ontology Provided by RefSeq

    Process Evidence Code Pubs
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pulmonary surfactant-associated protein B
    Names
    6 kDa protein
    SP-B
    pulmonary surfactant-associated proteolipid SPL(Phe)
    surfactant, pulmonary-associated protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001075311.2 → NP_001068779.1  pulmonary surfactant-associated protein B precursor

      See identical proteins and their annotated locations for NP_001068779.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118395
      UniProtKB/Swiss-Prot
      P15781, Q148E8
      Related
      ENSBTAP00000042549.3, ENSBTAT00000045134.5
      Conserved Domains (3) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111 → 142
      SapB_2; Saposin-like type B, region 2
      cl02494
      Location:29 → 60
      SapA; Saposin A-type domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037338.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      49329784..49340737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005212760.4 → XP_005212817.1  pulmonary surfactant-associated protein B isoform X1

      See identical proteins and their annotated locations for XP_005212817.1

      UniProtKB/Swiss-Prot
      P15781, Q148E8
      Conserved Domains (3) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      pfam03489
      Location:111 → 142
      SapB_2; Saposin-like type B, region 2
      cl02494
      Location:29 → 60
      SapA; Saposin A-type domain

    2. XM_015473479.3 → XP_015328965.1  pulmonary surfactant-associated protein B isoform X2

      Conserved Domains (2) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      cl02494
      Location:29 → 60
      SapA; Saposin A-type domain

    3. XM_024998422.2 → XP_024854190.1  pulmonary surfactant-associated protein B isoform X2

      Conserved Domains (2) summary
      smart00741
      Location:66 → 142
      SapB; Saposin (B) Domains
      cl02494
      Location:29 → 60
      SapA; Saposin A-type domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15781.3 GenPept UniProtKB/Swiss-Prot:P15781

    Gene LinkOut

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