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    CDC15 serine/threonine protein kinase CDC15 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851274, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CDC15
    Official Full Name
    serine/threonine protein kinase CDC15
    Primary source
    SGD:S000000072
    Locus tag
    YAR019C
    See related
    AllianceGenome:SGD:S000000072; FungiDB:YAR019C; VEuPathDB:YAR019C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LYT1; RLT1
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including meiotic spindle disassembly; negative regulation of protein localization to nucleolus; and regulation of cell cycle process. Located in cellular bud neck and spindle pole body. Orthologous to human MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CDC15 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (172211..175135, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene phosphoribosylaminoimidazolesuccinocarboxamide synthase Neighboring gene serine/threonine protein kinase KIN3 Neighboring gene seripauperin PAU7 Neighboring gene DUP240 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain. Schweitzer B, et al. Yeast, 1991 Apr. PMID 1882551
    2. Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions. Lopez V, et al. Genes Dev, 2015 Feb 1. PMID 25644606, Free PMC Article
    3. Costs, benefits and redundant mechanisms of adaption to chronic low-dose stress in yeast. Markiewicz-Potoczny M, et al. Cell Cycle, 2016 Oct 17. PMID 27628486, Free PMC Article
    4. A novel functional domain of Cdc15 kinase is required for its interaction with Tem1 GTPase in Saccharomyces cerevisiae. Asakawa K, et al. Genetics, 2001 Apr. PMID 11290702, Free PMC Article
    5. Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae. Pablo-Hernando ME, et al. Genetics, 2007 Sep. PMID 17660551, Free PMC Article

    See all (169) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
      Title: A Noncanonical Hippo Pathway Regulates Spindle Disassembly and Cytokinesis During Meiosis in Saccharomyces cerevisiae.
    2. Cdc15 also influences the complete transcription of clb2 gene and phosphorylates Ser-5 at the promoter and Ser-2 toward the 3' end of the gene
      Title: Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ascospore-type prospore membrane formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ascospore-type prospore membrane formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase CDC15
    NP_009411.2
    • Hippo-like kinase of the Mitotic Exit Network; promotes exit by activating the Dbf2p kinase; component of a non-canonical Hippo pathway with Sps1p required for prospore membrane closure, spindle disassembly and sustained release of Cdc14p during meiotic anaphase II; complexes with Sps1p and contributes to its phosphorylation; phosphorylates the RNAPII CTD during mitosis; localizes to the bud neck and SPB during anaphase and telophase; relocalizes to the cytoplasm upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      172211..175135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178218.2 → NP_009411.2  TPA: serine/threonine protein kinase CDC15 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009411.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPM6, P27636
      UniProtKB/TrEMBL
      A7A0H5, C7GUF8, N1P940
      Conserved Domains (1) summary
      cl21453
      Location:24 → 272
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27636.3

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