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    ARK1 serine/threonine protein kinase ARK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855711, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARK1
    Official Full Name
    serine/threonine protein kinase ARK1
    Primary source
    SGD:S000004965
    Locus tag
    YNL020C
    See related
    AllianceGenome:SGD:S000004965; FungiDB:YNL020C; VEuPathDB:YNL020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in actin filament organization; peptidyl-threonine phosphorylation; and regulation of clathrin-dependent endocytosis. Located in actin cortical patch. Orthologous to several human genes including AAK1 (AP2 associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARK1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (595623..597539, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene rRNA (cytosine-C5-)-methyltransferase RCM1 Neighboring gene histone deacetylase HDA1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Corra: Computational framework and tools for LC-MS discovery and targeted mass spectrometry-based proteomics. Brusniak MY, et al. BMC Bioinformatics, 2008 Dec 16. PMID 19087345, Free PMC Article
    2. A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway. Gerlach GJ, et al. PLoS Comput Biol, 2020 Sep. PMID 32925900, Free PMC Article
    3. An Abp1-dependent route of endocytosis functions when the classical endocytic pathway in yeast is inhibited. Aghamohammadzadeh S, et al. PLoS One, 2014. PMID 25072293, Free PMC Article
    4. Measurement of bond vector orientations in invisible excited states of proteins. Vallurupalli P, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18006656, Free PMC Article
    5. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. Sekiya-Kawasaki M, et al. J Cell Biol, 2003 Sep 1. PMID 12952930, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conserved Ark1-related kinases function in a TORC2 signaling network.
      Title: Conserved Ark1-related kinases function in a TORC2 signaling network.
    2. cells that overexpress AAK1 are adriamycin resistant
      Title: Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells.
    3. Data show that Sjl2p is specifically associated with cortical actin patches which aggregate upon loss of the actin-regulating kinases Ark1p and Prk1p.
      Title: Sjl2p is specifically involved in early steps of endocytosis intimately linked to actin dynamics via the Ark1p/Prk1p kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of clathrin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mating projection tip HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase ARK1
    NP_014378.1
    • Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      595623..597539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182859.1 → NP_014378.1  TPA: serine/threonine protein kinase ARK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014378.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1F9, P53974
      UniProtKB/TrEMBL
      A6ZS46, G2WM71, N1P4L5
      Conserved Domains (1) summary
      cd14037
      Location:18 → 301
      STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53974.1

    Gene LinkOut

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