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    VAC7 Vac7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855673, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VAC7
    Official Full Name
    Vac7p
    Primary source
    SGD:S000004999
    Locus tag
    YNL054W
    See related
    AllianceGenome:SGD:S000004999; FungiDB:YNL054W; VEuPathDB:YNL054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of kinase activity; positive regulation of phosphatidylinositol biosynthetic process; and protein localization to vacuolar membrane. Located in fungal-type vacuole membrane. Is integral component of membrane. Part of PAS complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See VAC7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (526086..529583)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tyrosine/serine/threonine protein phosphatase MSG5 Neighboring gene cytochrome c oxidase subunit Va

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary JD, et al. J Cell Biol, 1998 Oct 5. PMID 9763421, Free PMC Article
    2. Characterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation. Gomes de Mesquita DS, et al. Eur J Cell Biol, 1996 Nov. PMID 8929562
    3. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins. Levine TP. Proteins, 2022 Jan. PMID 34347309
    4. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Rudge SA, et al. Mol Biol Cell, 2004 Jan. PMID 14528018, Free PMC Article
    5. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary JD, et al. Mol Biol Cell, 2002 Apr. PMID 11950935, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
      Title: TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to vacuolar membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole inheritance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PAS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PAS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PAS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vac7p
    NP_014344.3
    • Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      526086..529583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182893.3 → NP_014344.3  TPA: Vac7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014344.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1C5, P53950
      UniProtKB/TrEMBL
      G2WM49, N1NZI9
      Conserved Domains (1) summary
      pfam12751
      Location:923 → 1001
      Vac7; Vacuolar segregation subunit 7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53950.1

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